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Disease/Therapeutics 2 Exam 1 > Sleep Drugs > Flashcards

Flashcards in Sleep Drugs Deck (21):
1

BDZs and sleep

ALTERED sleep structure
Increase stage 2
DEC stages 3,4
Tolerance develops

2

What is the longest time you can use a hypnotic for?

1 month

3

BDZs used for sleep

Temazepam (for frequent waking)
Triazolam (tolerance quickly..demand more pills; use intermittently

4

Zolpidem (Ambien)

Non-BDZ
Acts at BDZ receptor
PRESERVES SLEEP STRUCTURE

5

Zaleplon (Sonata)

Binds BDZ receptor
Can be dosed in MIDDLE OF NIGHT bc of short t1/2

6

Eszopicione (Lunesta)

Not restricted for short term use --- can be used longer but still not over a month

7

Barbiturates side effects

Drug tolerance
HYPERALGESIA
INC CYP metabolism (interactions)
Severe withdrawal
COMA at toxic doses
NO ANTIDOTE
Depresses CNS activity at low concentrations but muscle at high

8

BARB MOA

Same as BZs but open channels for longer periods of time
High doses - mimics GABA

AFFECTS SLEEP STRUCTURE

9

Thiopental

BARB used for induction of anesthesia

10

Contraindications of BARBS

Porphyria
Pregnant
Breast feeding

11

Narcotherapy (amobarbital, pentobarbital, thiopental)

Truth serum
Removes inhibitions to lie

12

Abstinence Syndrome

Chronic use of BARBS down regulates GABA receptors (INC cholinergic, INC glutamate receptors)
Can be life threatening
EXCITEMENT
Hospitalize and stabilize with lowest dose that prevents issues

13

Chloral Hydrate (Noctec)

Barb-like
Wide safety margin
+ alcohol = knock out drops
Less effective than BDZs

14

Melatonin

Pineal gland
From Tryptophan
Diurnal (peaks in middle of night, decreases in morning, increases at night)

15

Ramelton (Rozerem)

No abuse potential
Used in Children
Melatonin receptor agonist

16

EtOH

Low - stimulation
Additive with other depressants
USED for METHANOL or ETHYLENE GLYCOL Intoxication due to greater affinity of alcohol dehydrogenase for ethanol -- decreases toxic metabolites

17

What causes hangover symptoms?

Acetaldehyde

18

Disulfiram

Blocks aldehyde dehydrogenase causing high amounts of Acetaldehyde when a person drinks ... massive hangover

*treat alcoholism*

19

Narcolepsy Drugs

Nightime meds + daytime meds

Antidepressant, gamma hydroxybutyrate

ADHD meds (Modafinil)

20

Modafinil

Give at start of day
Not in kids

21

Gamma Hydroxybutyrate

Date rape drug