Small Group: Hepatitis and Acute Liver Injury Flashcards Preview

MS2 - Digestive, Endocrine, and Metabolic Systems > Small Group: Hepatitis and Acute Liver Injury > Flashcards

Flashcards in Small Group: Hepatitis and Acute Liver Injury Deck (20)
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1
Q

Which lobe of the liver is usually largest?

A

The right lobe

2
Q

The ______________ ligament divides the right and left lobes of the liver.

A

falciform

3
Q

True or false: Kupffer cells exist in the space of Disse.

A

False. They reside in sinusoids; cells of Ito reside in the space of Disse and between hepatocytes.

4
Q

Hemolysis can raise what “liver” lab?

A

AST

5
Q

Alkaline phosphatase is elevated in what three non-hepatic disorders/states?

A
  • Intestinal perforation (because alk phos is also in the intestines)
  • Pregnancy (because alk phos is also in the placenta)
  • Bone fractures (because alk phos is also in the bone)
6
Q

There are two ways in which liver dysfunction prolongs PT/INR: ______________.

A

(1) malabsorption of vitamin K due to failure of bile production and (2) impaired synthesis of the coagulation factors

7
Q

True or false: you normally can’t see bile ducts with microscopy.

A

True! You’ll only see them if they’re filled with bile.

8
Q

Describe the histologic appearance of steatohepatitis.

A

Neutrophils clustered around steatotic cells.

9
Q

Where (histologically) does autoimmune hepatitis present?

A

Around the portal tract

10
Q

What three names does the pink-body-containing cell have?

A

Acidophilic body, councilman body, or apoptotic cell

11
Q

True or false: acute alcohol binges can raise ALT and AST to the severe (15x normal) range.

A

False. This would be extremely unusual – combined with acetaminophen, maybe.

12
Q

Lymphocytes and macrophages will aggregate around a cell that has ___________ in acute viral hepatitis.

A

been infected and is now degenerating

13
Q

Upon staining, core antigen will be in the ____________.

A

nuclei of cells (hence the name)

14
Q

True or false: you don’t need cirrhosis from viral hepatitis to have increased risk of HCC.

A

True!

15
Q

Only _____ percent of those with chronic hepatitis B develop cirrhosis.

A

20

16
Q

What are Councilman bodies?

A

Degraded keratin (an intermediate filament) with ubiquitin

17
Q

Steatosis is reversible with ___________.

A

abstinence

18
Q

Other than metabolic syndrome and alcohol, what else can cause steatosis?

A

Drug reactions

19
Q

About _____ percent of alcoholics develop cirrhosis.

A

10

20
Q

Which of the autoimmune cholestatic diseases is associated with connective tissue disorders?

A

PBC (Sjögren’s, RA, SLE)

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