Small Group: Hepatitis and Acute Liver Injury Flashcards Preview

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Flashcards in Small Group: Hepatitis and Acute Liver Injury Deck (20):
1

Which lobe of the liver is usually largest?

The right lobe

2

The ______________ ligament divides the right and left lobes of the liver.

falciform

3

True or false: Kupffer cells exist in the space of Disse.

False. They reside in sinusoids; cells of Ito reside in the space of Disse and between hepatocytes.

4

Hemolysis can raise what "liver" lab?

AST

5

Alkaline phosphatase is elevated in what three non-hepatic disorders/states?

- Intestinal perforation (because alk phos is also in the intestines)
- Pregnancy (because alk phos is also in the placenta)
- Bone fractures (because alk phos is also in the bone)

6

There are two ways in which liver dysfunction prolongs PT/INR: ______________.

(1) malabsorption of vitamin K due to failure of bile production and (2) impaired synthesis of the coagulation factors

7

True or false: you normally can't see bile ducts with microscopy.

True! You'll only see them if they're filled with bile.

8

Describe the histologic appearance of steatohepatitis.

Neutrophils clustered around steatotic cells.

9

Where (histologically) does autoimmune hepatitis present?

Around the portal tract

10

What three names does the pink-body-containing cell have?

Acidophilic body, councilman body, or apoptotic cell

11

True or false: acute alcohol binges can raise ALT and AST to the severe (15x normal) range.

False. This would be extremely unusual – combined with acetaminophen, maybe.

12

Lymphocytes and macrophages will aggregate around a cell that has ___________ in acute viral hepatitis.

been infected and is now degenerating

13

Upon staining, core antigen will be in the ____________.

nuclei of cells (hence the name)

14

True or false: you don't need cirrhosis from viral hepatitis to have increased risk of HCC.

True!

15

Only _____ percent of those with chronic hepatitis B develop cirrhosis.

20

16

What are Councilman bodies?

Degraded keratin (an intermediate filament) with ubiquitin

17

Steatosis is reversible with ___________.

abstinence

18

Other than metabolic syndrome and alcohol, what else can cause steatosis?

Drug reactions

19

About _____ percent of alcoholics develop cirrhosis.

10

20

Which of the autoimmune cholestatic diseases is associated with connective tissue disorders?

PBC (Sjögren's, RA, SLE)

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