Flashcards in Small Group: Hepatitis and Acute Liver Injury Deck (20):
Which lobe of the liver is usually largest?
The right lobe
The ______________ ligament divides the right and left lobes of the liver.
True or false: Kupffer cells exist in the space of Disse.
False. They reside in sinusoids; cells of Ito reside in the space of Disse and between hepatocytes.
Hemolysis can raise what "liver" lab?
Alkaline phosphatase is elevated in what three non-hepatic disorders/states?
- Intestinal perforation (because alk phos is also in the intestines)
- Pregnancy (because alk phos is also in the placenta)
- Bone fractures (because alk phos is also in the bone)
There are two ways in which liver dysfunction prolongs PT/INR: ______________.
(1) malabsorption of vitamin K due to failure of bile production and (2) impaired synthesis of the coagulation factors
True or false: you normally can't see bile ducts with microscopy.
True! You'll only see them if they're filled with bile.
Describe the histologic appearance of steatohepatitis.
Neutrophils clustered around steatotic cells.
Where (histologically) does autoimmune hepatitis present?
Around the portal tract
What three names does the pink-body-containing cell have?
Acidophilic body, councilman body, or apoptotic cell
True or false: acute alcohol binges can raise ALT and AST to the severe (15x normal) range.
False. This would be extremely unusual – combined with acetaminophen, maybe.
Lymphocytes and macrophages will aggregate around a cell that has ___________ in acute viral hepatitis.
been infected and is now degenerating
Upon staining, core antigen will be in the ____________.
nuclei of cells (hence the name)
True or false: you don't need cirrhosis from viral hepatitis to have increased risk of HCC.
Only _____ percent of those with chronic hepatitis B develop cirrhosis.
What are Councilman bodies?
Degraded keratin (an intermediate filament) with ubiquitin
Steatosis is reversible with ___________.
Other than metabolic syndrome and alcohol, what else can cause steatosis?
About _____ percent of alcoholics develop cirrhosis.