Soft tissue sarcomas Flashcards by Aimee Soileau

A recent retrospective study evaluating adjuvant radiotherapy in 18 cats with non-injection site soft tissue sarcoma was performed. Overall recurrence rate following RT was ___% with a LR rate of ____% for hypofractionated RT and a LR rate of ___% for conventionally fractionated RT. The overall median PFI was _____, while the median PFI for cats with recurrence was _____. There was no significant difference in PFI in hypofractionated and conventionally fractionated RT protocols with a PFI of ____ for hypofractionated RT and ____ for conventionally fractionated RT.

oLR: 44%
LR hRT: 38%
LR cRT: 50%
oPFI: 7.5 years
PFI recurrence: 5 months
PFI hRT: 6mo
PFI cRT: 7.5 years

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Feline giant-cell pleomorphic sarcoma is characterized by what cells on cytology/histology?

spindle cells, small round cells, and multinucleated giant cells

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Histological and IHC features was evaluated in 9 cats with piloleiomyosarcoma. What was found to affect clinical outcome?

mitotic count
infiltration of SQ tissue
intensity of nuclear immunolabeling for p53

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A recent retrospective study evaluating the biologic behavior and ezrin expression in 25 dogs with non-urinary rhabdomyosarcoma was performed. The median age was _____. _______ and _______ were the most common primary tumor locations. ____% had metastasis at time of diagnosis. What tumor type was often diagnosed initially in 32% of cases? What was the MST? Of the cases sampled, ___% stained positive for ezrin.

2 years
SQ and retrobulbar/orbital
64%
round cell tumor
MST: 10 days
95%

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Outcomes in 41 dogs with high grade STS were assessed following definitive-intent RT with or without chemotherapy were recently assessed. The median OST was _____. The mean TTP was ______ (median not reached). ___% developed metastasis, and ___% developed recurrence. What factors were negatively associated with progression and death?

oMST: 33 months
mean TTP: 53 months
Met: 24%
LR: 20%
progression: increased MC and prolonged RT duration
death: prolonged RT duration and length of surgical scar

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***A retrospective study evaluating outcomes associated with primary abdominal visceral soft tissue sarcomas in 42 dogs was performed. What was the most common tumor type and locations? Local recurrence rate was ___%. Metastasis was present at time of surgery in __% and the overall metastatic rate was ___%. Mitotic count of ___ was associated with significantly shorter survival time of _____ compared with a mitotic count of ___ (MST not reached). The MST for grade 1 STS was ____, grade 2 ______, and grade 3 _____.

leiomyosarcoma
spleen and small intestine
LR: 5%
met at diagnosis: 24%
overall met: 40%
> or equal to 9; 9 months
< 9
grade 1 MST: not reached
grade 2 MST: 20 months
grade 3 MST: 5 months

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A grading system was recently proposed in cats with STS evaluating what 3 factors? The MST for low grade was ____, intermediate grade _____, and high grade _____.

MC, necrosis, inflammation
MST low grade: 30 months
MST intermediate grade: 17 months
MST high grade: 9 months

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***Retrospective comparison between definitive-intent finely fractionated and palliative-intent coarsely fractionated RT for microscopic post-operative feline injection site sarcoma was performed. PFI was not significantly different between protocols except when only first-occurrence cases were included. The median PFI in finely fractionated group was _____ and the median PFI in coarsely fractionated group was ______. The overall PFI was _____.

finely fractionated RT: 48 months
coarsely fractionated RT: 18 months
oPFI: 5.5years

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Fibrosarcoma has a higher predilection in _____ and ______ breeds in one study. dogs with FSA are significantly _____ than dogs with other histologic subtypes.

Goldens and Dobies
younger

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***What is a preferred name for malignant fibrous histiocytoma?

undifferentiated pleomorphic sarcoma

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What 3 breeds are over-represented for pleomorphic sarcoma/malignant fibrous histiocytoma?

flat-coated retrievers
Goldens
Rotties

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Pleomorphic sarcoma/malignant fibrous histiocytoma is most commonly diagnosed in what locations?

SC of the trunk
pelvic limbs
spleen

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Name the 4 subtypes of pleomorphic sarcoma/malignant fibrous histiocytoma and identify which one has high local recurrence and metastatic potential.

Storiform-pleomorphic
Myxoid
Giant cell: higher LR and higher met rate
Inflammatory

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The giant cell subtype of pleomorphic sarcoma/malignant fibrous histiocytoma has been described in 10 dogs. It was found to be highly metastatic to which sites and what was the MST?

high met: SC tissue, LN, liver, and lungs
MST 2 mo

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Perivascular wall tumors arise from different cellular components of the vascular wall, excluding the endothelial lining. What is the IHC staining of these tumors, including the different cell types?

pericytes: vimentin+, pan actin+, alpha-smooth muscle actin +/-
myopericytes: desmin+, calponin+
smooth muscle cells: smoothelin+ and heavy caldesmon+

Negative: S-100-, NSE-, GFAP-, myoglobin-

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What is the IHC staining pattern for pleomorphic sarcoma/malignant fibrous histiocytoma?

Postive: vimentin+, lysozyme +/-, MHCII+/-, desmin +/-

Negative: CD18-, S-100-

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***How can a PNST be differentiated from a PWT on IHC?

PNST:
- Positive: Vimentin+, S-100+/-, GFAP+/-, NGFR+/-, NSE+/-, NF+/-, myoglobin+/-

typically have significantly higher Ki67 index than PWT

PWT: Negative for S-100, NSE, GFAP, and myoglobin

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In a study of 16 dogs with brachial plexus PNSTs treated with limb-sparing compartmental resection, the oMST was ____. The MST for complete excision was ____ and the MST for incomplete excision was ____.

oMST: 43mo
MST complete: 6 years
MST incomplete: 16mo

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Stereotactic RT in 10 dogs with brachial plexus tumors resulted in improvement or resolution of neurologic signs in ___%, PFS of ____, and MST of ____.

improved/resolved neuro: 100%
PFS: 8mo
MST: 12mo

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Staining cytologic samples with _____ can be useful to differentiate liposarcoma from other soft tissue sarcomas by staining lipid.

Oil Red O

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***The reported MST for dogs with liposarcoma who undergo wide surgical excision is _____, ______ for marginal excision, and ____ for incomplete excision.

MST:
- wide: 40mo
- marginal: 22mo
- incomplete: 6mo

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What two IHC markers can be used for liposarcoma? Name the histologic subtypes and their % staining frequency for one of the markers.

MDM2 and CDK4

MDM2
- Well differentiated: 67%
- pleomorphic: 0%
- myxoid: 14%
- Dedifferentiated: 75%

Majority of subtypes stain + for CDK4 with dedifferentiated subtype being most common at 100%

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Rhabdomyosarcoma in dogs is most frequently reported to arise from skeletal muscle of the ______, _____, _____, _____, and _____.

urinary bladder
retrobulbar musculature
larynx
tongue
myocardium

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Describe the histologic classifications of rhabdomyosarcoma and list metastatic rates if identified. Be sure to list location predilections and breed predispositions if any.

Embryonal:
- predilection for head and neck region
- met rate: 50%
Botryoid:
- urinary bladder of young, female, large breed dogs (St. Bernards)
- grape-like appearance
- met rate: 27%
Alveolar:
- met rate: 50%
Pleomorphic

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***What is the IHC staining fro rhabdomyosarcoma?

Positive: vimentin, skeletal muscle actin, myoglobin, myogenin, myogenic differentiation (MyoD), desmin, S-100+/-, NSE+/-, GFAP+/-

In one study of orbital rhabdoymyosarcoma in dogs, all dogs ____ of age died of metastatic disease or LR whereas dogs ____ of age did not die of tumor-related reasons. The MST for those dogs that died from tumor-related reasons was _____.

<4 years: all died >4 years: none died from tumor related reason <4 years MST: 3mo

***IHC for lymphatic endothelial cells to differentiate lymphangiosarcoma from HSA in dogs?

PROX-1 and LYVE1+ 100% express Factor VIII-related antigen like HSA

In a series of 12 dogs with lymphangiosarcoma, the MST with no treatment was ____, MST for surgery alone was _____, and MST in 1 dog who received surgery, RT, and chemotherapy was _____. All dogs were euthanized because of _______________.

MST: - No tx: 6mo - sx alone: 16mo - sx + RT + chemo: 19mo - all dogs died from recurrence or progressive local disease

Outcome for dogs with splenic mesenchymoma is better than for those with other types of splenic sarcoma with a reported MST of _____.

MST 12mo

***Determination of histologic grade from pre-operative biopsies in dogs with STS were incorrect in ____% compared with definitive surgical sample. Underestimation was reported in ___% and overestimated was reported in ____%.

- incorrect: 41% - underestimation: ~30% - overestimate: ~10%

Dogs with complete histologic excision of STS are ___x less likely to have local tumor recurrence compared with dogs with incompletely excised STS.

10.5x

Marginal excision of canine STS may be an acceptable treatment option for well-circumscribed, non-infiltrative tumors less than ____ cm in diameter and located ________________.

<5cm located at or below stifle or elbow

In a study of 236 dogs with SC STSs treated with excisional biopsy, LR for completely excised tumors was ____%. Recurrence rate was dependent on grade for incompletely excised tumors with grade I being ___%, grade 2 being ___%, and grade 3 being ___%

- complete LR: 0% - incomplete grade I: 7% - incomplete grade 2: 34% - incomplete grade 3: 75%

In 2 studies of dogs with PWTs, overall LR was ___-___%. For incompletely excised tumors, LR occurred in ___-___%. Prognostic factor for these studies was tumor size. Local recurrence was up to 7x more likely for PWTs greater than _____ in diameter.

- oLR: 18-20% - LR incompletely excised: 60-63% - >5cm

In a study of 350 STSs in dogs treated surgically in non-referral practices, wide margins were performed in 5% of cases. LR rate was ___%. Histologic grade was the only prognostic factor for recurrence.

- 21%

***Active surveillance in dogs with incompletely excised STSs may be appropriate with:

grade 1 and possibly grade 2 tumors with favorable characteristics: - well circumscribed tumors - diameter <5cm - location on either thoracic or pelvic limb at or below elbow or stifle

In a study of 39 dogs with STS where the surgical scar was excised with 0.5-3.5cm lateral margins, histologic evidence of residual tumor was ___%.

- 22%

Electrochemotherapy (bleomycin injected into the tumor bed) in the management of incompletely excised high-grade STSs in 22 dogs reported a LR rate of ___%, mean time to recurrence of ____ and wound dehiscence in ___%.

- LR: 36% - Mean time to recurrence: 24mo - wound dehiscence: 14%

***RT should be started at a minimum of _____ post-operatively for STS in dogs to minimize delayed healing and dehiscence.

7 day minimum

Cumulative doses of ____Gy are recommended for adjunctive fractionated RT for treatment of incompletely excised STS because local tumor control is better with higher cumulative doses.

>50Gy

The local tumor recurrence rate following surgery + fractionated RT in dogs with STS ranges from ___-___% with 4 year control reported to be up to ____%.

16-35% 4 year control: up to 81%

Median time to recurrence following surgery and fractionated RT for dogs with STS is significantly shorter for grade 3 tumors at _____ compared to grade 1 and 2 tumors at _____.

- grade 3: 3mo - grade 1 or 2: >47mo

Incompletely resected nonoral STSs in dogs with post-operative fractionated RT report a MST of _____ and 5-year survival of ___%.

- MST: 6 years - 5 year survival: 76%

In one study, dogs with STSs with a MI > ____ were more likely to have local recurrence and shorter ST.

MI >9/10HPF

***Hypofractionated RT following surgery in dogs with STS has a local recurrence rate of ___-___% with majority of dogs in these studies having small grade 1 or 2 tumors. PFI was _____-______ with a 3-year control rate of ____%. In one study, delaying hypofractionated RT for _______ after surgery was associated with an IMPROVED outcome. Histologic grade was prognostic for both PFS and OST in one study. Dogs with grade 3 tumors had a significantly shorter PFS at ____ compared to dogs with grade 2 at _____ and grade 1 at ______. Median tumor-specific OST was _____ for grade 3 and _____ for grade 1 and 2.

- LR: 18-21% - PFI: 23mo - not reached - 3 year control rate: 73% - more than 4 weeks delay = improves outcome PFS: - grade 3: 10mo - grade 2: 19mo - grade 1: 5.2years Tumor-specific OST: - grade 3: 31mo - grade 1 or 2: not reached

Radiation therapy for macroscopic STS in dogs using a cumulative dose of 50Gy has a reported 1-year control of ____% and 2 year control of ____%.

- 1 year control: 50% - 2 year control: 33%

One study reported a CR rate of ____% for macroscopic STS treated with RT alone, but tumors did NOT rapidly regress after RT.

- CR: 30%

The overall response rate of macroscopic STS in dogs to hypofractionated RT is ___%. PFI ranges from ____-_____, which is dependent on tumor location and previous surgeries. The PFI for limb STSs was _____ vs. _____ for head and trunk. MST for limb STS is _____, _____ for head, and ____ for trunk.

- ORR: ~50% - PFI: 5mo - 14mo - Limb PFI: 16mo - Head/trunk PFI: 4mo - MST limb: 19mo - MST head: 6mo - MST trunk: 6mo

About 40% of dogs in one study with macroscopic STS were treated with hypofractionated RT +/- metronomic chemotherapy. MC did NOT improve PFIs but did significantly improve MSTs. MST for dogs who received RT + MC was ____ compared to those who received RT alone at ____.

MST: - hypofractionated RT + MC: 25mo - hypofractionated RT alone: 17mo

What is the metastatic rate for grade 1, 2, and 3 STSs in dogs? What is the median time to metastasis?

- grade 1: 0-13% - grade 2: 7-27% - grade 3: 22-44% - median time to met: 12mo

Intralesional chemotherapy into surgical bed and 5-FU IV weekly treatments for dogs with incompletely excised STS resulted in wound complications of ____-____%.

47-84%

Overall LR rates for dogs with STS after wide resection are ___-___%, incomplete histologic excision are ___-___%, incomplete excision and fractionated RT are ___-___%, incomplete excision and hypofractionated RT are ___-___%.

LR: - Wide excision: 0-5% - incomplete excision: ~10-30% - incomplete excision + fRT: 17-37% - incomplete excision + hRT: 18-21%

***What are poor prognostic factors for local tumor control in dogs with STS?

- large tumor size, >5cm - infiltrative tumors - tumors in locations other than at or below stifle or elbow - histologic subtypes - Grade III STSs - incomplete surgical margins

_____ STS histologic subtype in dogs has a low risk of recurrence and _____ subtype has a high risk of recurrence.

- PWT: low risk - FSA: high risk

The overall metastatic rate for STS in dogs ranges from ___-___%. What factors increase risk of metastasis?

- Met rate: 0-31% Increase risk: - histologic grade - number of mitotic figures - percentage of tumor necrosis - local tumor recurrence

Metastasis is 5x more likely when tumors have a mitotic rate ______.

>/= 20/10hpf

The MST for dogs with non-oral STS treated with surgery alone are ____-_____ and up to _____ for dogs treated with surgery and adjuvant RT.

MST: - Sx alone: 3.8-4.9 years - Sx + adjuvant RT: 6.2 years

____-___% of dogs with STS eventually die of tumor-related causes after curative-intent treatment.

9-33%

Dogs with STS treated with wide surgical excision have a MST of _____, ______ with non-curative surgery, and _____ with incompletely excised tumors.

MST: - Wide: >3.5 years - non-curative sx: 9mo - incomplete excision: 22mo

***What features are associated with survival in dogs with STS?

1. Tumor necrosis 2. Ki67 index 3. AgNOR index 4. Histologic grade 5. Mitotic rate

***The MST for dogs with STS and a MI <10 is ____, ____ with MI 10-19, and ____ with MI >/= 20.

MST: - MI <10: 48mo - MI 10-19: 18mo - MI >/= 20: 8mo

***Histologic grade was found to be prognostic for survival in two adjuvant RT studies. The study evaluating fractionated RT reported a MST of _____ for grade I, _____ for grade 2, and ____ for grade 3. The study evaluating adjuvant hypofractionated RT reported a MST of _____ for grade I, ____ for grade 2, and _____ for grade 3.

Sx + fractionated RT: - MST grade 1: not reached - MST grade 2: > 4 years - MST grade 3: 3mo Sx + hypofractionated RT: - MST grade 1: not reached - MST grade 2: not reached - MST grade 3: 31mo

***Dogs with ______ and ______ are 5x more likely to die from their STS.

- tumor recurrence - grossly invasive and fixed tumors

Dogs with STS with an increased AgNOR score are ___x more likely to die from their disease. Dogs with an increased Ki67 score are ____ more likely to die from their disease. MST for dogs with Ki67 above median was _____ and ____ for AgNOR above the median.

AgNOR above median: - 77x more likely to die - MST: >44mo Ki67 above median: - 12x more likely to die - MST: 22mo

***What are positive staining markers in feline ISS not seen in non-ISS?

- PDGF (lymphocytes) - PGFR (neoplastic cells and macs) - EGF and its receptors - TGFB - TGFa - p53 - bFGF - c-jun

___% of feline ISSs are grade 3.

60%

Up to ___% of peritumoral lesions seen with feline ISS are non-neoplastic when examined histologically.

- 60%

____% of feline ISSs are completely excised with 2-3cm lateral margins. In contrast, ___% of ISSs are completely excised when removed with 4-5cm lateral margins.

- 50% - 95-97%

Median time to first recurrence after marginal resection is _____ vs. _____ - _____ after wide resection or radical surgery in feline ISS.

- Marginal median time to LR: 3mo - Wide/radical median time to LR: 11-14mo

The median time to first recurrence when 1st surgery for feline ISS is performed by rDVM is ____ compared to _____ at a referral institution.

- rDVM time to LR: 2mo - referral time to LR: 9mo

***When feline ISS is resected with 5cm lateral margins and 2 fascial layers, complete excision rate is ___% and LR at 3 years is ____%. The MST ranges from ____-_____.

- Complete: 97% - LR at 3 years: 14% - MST: 27 months - not reached

***Compartmental resections of interscapular ISSs in combination with neoadjuvant epirubicin in 21 cats reported a LR rate of ___% at a median follow up time of ____.

LR 14% at median follow up of 3 years

Wound dehiscence occurs in cats after surgical management of ISS in ___-___% and is increased with ______ and ______.

- 11-17% increased: - wide excision of interscapular ISS compared to other locations - wound defects closed in an X-shape rather than linearly

Local tumor recurrence of feline ISS following surgery and RT ranges from ____-___%. The majority recur within the RT field. MSTs range from _____-____.

LR: 28-45% MST: 20-44mo

In two studies investigating pre-operative RT for feline ISS, local tumor recurrence was ___-___% at a median time to recurrence of ____-____. DFI for completely excised tumors was _____-_____ and DFI for incompletely excised tumors was ____-____. Complete resection after pre-op RT did NOT appear to improve local control rate.

- LR: 40-45% - Time to recurrence: 13-20mo - DFI complete: 23-33mo - DFI incomplete: 4-10mo

The outcome after post-operative RT is similar to pre-operative RT for feline ISS. In one study, LR of 76 cats treated with post-operative RT was ____% at a median time of _____. In a study investigating the effects of chemotherapy in cats treated with surgery and RT, median time to recurrence was ____ for cats treated with surgery and RT and ____ for cats also treated with doxorubicin. Lastly, in a study of 46 cats treated with surgery and curative-intent post-op RT, PFI was ____, 2 year progression free rate was ___%. In comparison to 27 cats in this study were treated with hypofractionated protocol after surgery and reported a PFI of ____ and MST of _____.

1st study: - LR: 41% at median of 14mo 2nd study: - time to recurrence surgery + RT: not reached - time to recurrence surgery + RT + DOX: 22mo 3rd study: - PFI: 37mo - 2 year PFS: 60% - PFI hRT: 10mo - MST: 24mo

RT for feline ISS should start _____ post-operatively as DFI and ST decreases as the interval between surgery and starting RT increases.

10-14 days

In a pilot study of 10 cats with macroscopic ISSs treated with liposomal DOX as a radiation sensitizer and irradiation with a median of 5 fractions of 4 Gy for a total dose of 20Gy, the ORR was ___% but was not durable with a PFI of ____. Similar findings were reported in 17 cats with gross disease treated with 4 fractions of 8Gy with a PFI of ____ and MST of ___.

1st study: - ORR: 90% - PFI: 4mo 2nd study: - PFI: 4mo - MST: 7mo

SRT has been described in a series of 11 cats with macroscopic ISS - most commonly using 3 fractions of 10Gy. The ORR was ___%

Metastasis occurs in ___-___% of cats with ISSs at a median time of ____-___ and is dependent on grade. Grade 1 tumors have a metastatic rate of ___-___%, grade 2 tumors have a metastatic rate of __-___%, and grade 3 tumors have a metastatic rate of ___-___%.

- Met: 0-26% at median 9-10mo - met grade 1: 0-17% - met grade 2: 15-19% - met grade 3: 22-100%

Partial or complete responses to DOX, either alone or in combination with Cytoxan or CCNU for macroscopic feline ISS have been reported in ___-___%. MST is significantly longer in cats that respond to treatment at ___ compared to ____ for non-responders.

- RR: 25-50% - MST responders: 8mo - MST non-responders: 3mo

MSTs are significantly increased for cats with ISS that have gross residual disease after surgical excision and treated with post-operative RT and chemotherapy. Combination therapy resulted in MST of ____ compared to ___ for surgery and post-op RT.

MST: - Sx + RT + chemo: 29mo - Sx + RT: 5mo

Post-operative chemotherapy has minimal effect on survival in cats with ISS treated with curative-intent surgery and RT but may have beneficial effects on local tumor control and time to local recurrence. DOX and Doxil significantly prolonged DFI after surgery with DFI of ___ compared to cats NOT receiving chemotherapy at ____.

DFI: - Chemo tx cats: 13mo - no chemo: 3mo

_______ chemotherapy yielded an insignificant but numerically superior DFI of >33mo in cats with ISS treated with pre-op RT and surgery.

carboplatin

In a study of cats with high-grade STSs treated either intraoperatively or post-operatively with intratumoral bleomycin followed by 8 biphasic pulses of 1300V/cm, median time to recurrence in control group (surgery only) was ____, ____ for intraop group, and ____ for post-op group. Metastatic rate was ___%.

Median time to LR: - control: 4mo - intraop: 12mo - postop: 19mo

In a study of 64 cats with FSA treated post-operatively with 2 rounds of ECT using cisplatin, ____% developed LR.

29%

Cats treated with surgery, iridium-based brachytherapy +/- recombinant viruses expressing IL-2, 1 year LR rates for cats receiving NO adjuvant treatment was ___%, ___% for cats administered human IL-2 using vaccinia virus vector, and ___% for cats administered feline IL-2 using canary pox virus.

1-year LR rate: - No adjunctive tx: ~60% - human IL-2: ~40% - Feline IL-2: ~30%

Local recurrence following complete excision of feline ISS occurs in ___-___%. LR rate for incomplete excision is ____-___%.

LR: - complete: 14-22% - incomplete: 60-70%

***Following wide resection with 5 cm lateral margins or compartmental resection of feline ISS, 3-year disease free rate is ___%.

86%

Name 4 prognostic factors for local recurrence in feline ISS.

1. Tumor grade 2. Tumor size 3. Surgical dose 4. Completeness of excision

The MST for cats with ISS treated with less aggressive surgery ranges from ___-___.

MST: >13mo - 20mo

***Name 7 prognostic factors associated with survival in cats with ISSs.

1. Anemia 2. Tumor size 3. Treatment type 4. Histologic subtype 5. Mitotic rate 6. Local tumor recurrence 7. Metastatic disease

Cats with ISS treated with surgery and RT with a PCV <25% have a MST of _____ compared to cats with a PCV >/=25% at ____.

MST: <25%: 10mo >/=25%: 25mo

Most studies do not show differences between cats with ISS treated with pre- or post-operative RT. In one study, the outcome was significantly worse for cats treated with pre-op RT than post-op RT. MST for pre-op RT was _____ and MST for post-op RT was ____.

MST: - pre-op: 10mo - post op: 24mo

***In a study of 52 cats treated with surgery alone, histologic subtype was prognostic. MST for cats with FSA was ____, ____ for PNST, and ____ for MFH.

MST: - FSA: 21mo - PNST: 22mo - MFH: 10mo

In a study of 24 cats with ISS, mitotic rate was prognostic for survival. Cats with MI >20 had a MST of ____ compared to ____ for those with MI

MST: - MI >20: 33mo - MI

The MST for cats with ISS who develop distant metastasis ranges from ____-____.

MST: 6-13mo

What % of grade III PNST have been reported to invade the spinal cord?

50%

Describe the grading scheme for STS.

Differentiation: - well differentiated: 1 - histologic type: 2 - poorly differentiated: 3 MI: - /=20: 3 Necrosis: - none: 1 - <50%: 2 - >50%: 3 Score - 1-4: grade 1 - 5-6: grade 2 - >/=7: grade 3

A recent retrospective study evaluating outcome and prognostic indicators for hemangiopericytomas in 167 dogs found that _____ was the most common location. ____ and ____ locations were associated with fastest recurrence at a median DFI of ____.

- distal forelimb - perineum and tail - DFI 16mo

SBRT for treatment of STS in 35 dogs was recently retrospectively assessed. The ORR was ___% with a CR of ___% and PR of ___%. PFS was ____ and TTP was _____. MST was ____ and DSS was ____.

- ORR: 46% - CR: 11% - PR: 36% - PFS: 17mo - TTP: 24mo - MST: 24mo - DSS: 38mo

Outcome and surgical treatment of canine STS in the region of ischiatic tuberosity was recently assessed. The OST and PFS for grade 1 or 2 tumors was _______. The OST and PFS for grade 3 tumors was _____. Time to LR for grade 1 or 2 tumors was ____ and ____ for grade 3 tumors. Surgical complication rate of ___%.

- OST/PFS grade 1/2: not reached - OST/PFS grade 3: 9mo (both) - Time to LR grade 1/2: not reached - Time to LR grade 3: 13mo - sx complication rate: 25%

Soft tissue sarcomas Flashcards

(102 cards)