Sorting Motifs/prokaryotic v. eukaryotic protein sorting Flashcards Preview

Biochemistry 431 > Sorting Motifs/prokaryotic v. eukaryotic protein sorting > Flashcards

Flashcards in Sorting Motifs/prokaryotic v. eukaryotic protein sorting Deck (10):
1

What are the four requirements of sorting into cellular compartments?

1) Sorting Motif Recognition 2) transport with the aid of chaperones 3) movement into or across a membrane 4)association of preproteins with chaperones

2

Inner membrane sorting motif in bacteria

one of the only sorting motifs in bacteria; location of the signature is at the amino terminus; +/hydrophobic/polar

3

ER sorting motif

LOS: amino terminus; TOS: +/hydrophobic/polar

4

Nuclear import sorting motif

LOS: amino terminus; TOS: +/PKKKRKV

5

Nuclear export sorting motif

LOS: amino terminus; TOS: leucine rich (LQLPPLERLTL)

6

Mitochondrial sorting motif

LOS: amino terminus; +/amphiphillic a-helices

7

Peroxisomes sorting motif

LOS:carboxy-terminus; TOS: SKL

8

ER retention sorting motif

LOS: carboxy terminus TOS:4

9

Lysosomes and endosomes sorting motif

LOS: carboxy-terminus TOS: KDEL

10

N-terminus sorting sequences

are often cleaved after their job is done

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