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Flashcards in Special products Deck (17):
1

Parkinson's disease is the result of alpha synuclean being incorporated into dopagenic neurons. What is the chemical discussed in class that can relieve symptoms of parkinson's?

DOPA

2

What is the enzyme responsible for synthesis of DIT and MIT in the T3/T4 pathway?

Peroxidase

3

What is the protein called that stores Y residues

Thyroglobulin

4

Melanin is the result of what initial enzyme reaction

Tyrosinase conveting Y into DOPA, then to Dopaquinone.

5

Oculocutaneous albinism type I is the result in a defect in what enzyme? What the symptoms and complications?

Tyrosinase
Lack of pigmentatiion
skin tumors, eye issues

6

Serotonin is made from which amino acid?

W

7

What is the enzyme that convert W to 5-hydroxytryptophan?

tryptophan hydroxylase

8

Niacin synthesis begins with what enzyme acting on what amino acid?

IDO on W

9

What does IDO generate? What role does IDO play in cancer?

N-formylkynureine.
Ido produces metabolites that inhibit the synthesis of T-cells

10

What is the enzyme that catalyzes histadine to histamine?

Pyridoxal phosphate

11

What is the enzyme that catalyzes E to GABA?

Pyridoxal phosphate

12

Glutathionine is made from which three amino acids?

E-C-G with a gamma glutamyl linkage

13

What role does glutathionine play?

Protects RBCs from oxidation by being oxidized to GSSG.

14

What enzyme catalyzes the reduction of GSSG to glutathionine? What high energy molecule is needed? (NADH, NADPH, FADH, or ATP?)

Glutathione reductase
NADPH

15

What enzyme catalyzes the oxidation of glutathione?

Glutathione peroxidase.

16

Glutathino also plays a role in liver detoxification. What enzymes we discussed plays a role in this?

Glutathione S-transferases

17

Where does the nitrogen in creatine come from?

R and G