Stem Cell Transplant Flashcards Preview

THERAPEUTICS III TEST 4 > Stem Cell Transplant > Flashcards

Flashcards in Stem Cell Transplant Deck (13):
1

why are stem cell transplants given in chemo patients?

bone marrow suppression limits chemotherapy; HSCT allows for bone marrow replenishment so higher doses of chemo can be given

2

what are indications for autologous stem cell transplants

1. multiple myeloma
2. some non-hodgkins lymphoma
3. hodgkins disease
4. neuroblastoma
5. germ cell tumors

3

what are the indications for allogeneic stem cell transplant (cancer related on)

1. leukemia
2. lymphoma
3. myelodysplastic syndrome

4

what percent of bone marrow cells are hematopoietic stem cells

0.01%

5

what drug can mobilize peripheral blood stem cells but doesn't cause them to proliferate?

mozobil (plerixafor)

6

how many stem cells are needed for a transplant

between 2 to 5 million stem cells/ kg

7

what are some stem cell transplant complications

1. mucositis, n&v
2. infections
3. pulmonary complications
4. sinusoidal obstruction syndrome (SOS)
5. GVHD

8

what are some stem cell transplant complications

1. mucositis, n&v
2. infections
3. pulmonary complications
4. sinusoidal obstruction syndrome (SOS)
5. GVHD

9

what is the dose limiting toxicity for melphalan

mucositis

10

what are 3 very common drugs given for infection prophylaxis with a stem cell transplant

1. fluconazole
2. acyclovir
3. levofloxacin

11

what is GVHD

graft versus host disease; donor t-cells attack the host

12

what must be given to allogeneic stem cell transplant patients to prevent GVHD

1. tacrolimus
2. steroids
3. . methotrexate

13

how is GVHD treated

high dose methylprednisolone