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Anesthesia Drug Test Quick Facts > steroids > Flashcards

steroids Flashcards

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1
Q

trade name of dexamethasone

A

decadron

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2
Q

how is dexamethasone supplied

A

4mg/mL
or
10mg/mL

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3
Q

MOA of decadron

A

primarily as an anti-inflammatory or immunosuppressant agent in the treatment of a variety of diseases

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4
Q

disease dexamethasone treats

A 
allergic
dermatologic
gastrointestinal
endocrine
hematologic
inflammatory
neoplastic
nervous system
ophthalmic
renal
respiratory
rheumatic
autoimmune
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5
Q

conditions dexamethasone treats

A

cerebral edema
chronic swelling
diagnostic agent for cushiness
antiemetic

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6
Q

MOA of dexamethasone

A

Decerases inflammations by:

1) suppression of neutrophil migration
2) decreased production of inflammatory mediators
3) reversal of increased capillary permeability
4) suppresses normal immune response

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7
Q

MOA of dexamethasone’s antiemetic activity

A

unknown

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8
Q

anti-inflammatory dose of oral, IM, IV dexamethasone

A

0.75-9 mg/day

divided into doses every 6-12 hours

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9
Q

intra-articular, intralesional or soft tissue dose of dexamethazone

A

0.4-6 mg/day

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10
Q

extubation or airway edema dose of dexamethasone oral, IM, IV

A

0.5-2 mg/kg/day

dividd into doses every 6 hours 1st 24 hours prior to extubatoin and continuing for 4-6 doses afterwards

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11
Q

antiemetic prophylaxis dose of dexmethasone oral or IV

A

10-20 mg 15-30 minutes before treatment on each treatment day

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12
Q

mild emotogenic dose of dexemethasone ORal, IM, IV

A

4 mg every 4-6 hours

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13
Q

cerebral edema dose IV of dexamethasone

A 
10 mg STAT
4 mg IM/IV
give as sodium phosphate every 6 hours until max response then go oral, and tapper if needed 
reduce dose 2-4 days
done 5-7 days
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14
Q

treatments of shock dose of dexamethasone

A

4-10 mg as single dose
repeat if needed
Adisonian crisis

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15
Q

unresponsive shock treatments of shock dose of dexamethasone

A

1-6 mg/kg as a single IV dose or unto 40 mg initially repeat boluses 4-6 hours while shock persists

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16
Q

physiological replacement dose ORAL IM IV dexamethasone dose

A

0.03-0.15 mg/kg/day or 0.6-0.75 mg/m2/day in divided doses every 6-12 hours

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17
Q

dexamethasone onset of action

A

prompt - IV

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18
Q

dexamethasone half-life

oral vs IV

A

oral 4 hours

IV 1-5 hours

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19
Q

peak in serum dexamethasone

A

1-2 hours
IM 30-120 minuts
IV 5-10 minutes

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20
Q

excretion of dexamethasone

A

urine

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21
Q

adverse reactions of dexamethasone

Study These Flashcards
A

NUMEROUS

CV, NEURO-mood, SKIN, DM, Abdominal, Joints, Eyes, wounds, infections

22
Q

contraindications with dexamethasone

Study These Flashcards
A

sulfite allergy
systemic fungal infections
cerebral edema

23
Q

trade name of hydrocortisone

24
Q

how is hydrocortisone supplied

25
what is hydrocortisone used for
``` anti-inflammatory immunosuppresion for: dermatologic endocrine GI hematologic allergic inflammatory neoplastic neurologic opthlamic renal respiratory autoimmune ```
26
MOA of hydrocortisone
decreases inflammation by suppression of migration of PMN leukocytes reversal of increased cap peremeability
27
what 2 big conditions is hydrocortisone indicated in
septic shock- when BP is not responding to fluids and vasopressors Thyroid storm
28
stress dose for surgical pt already known to be adrenally-suppressed or on chronic systemic IV steroids minor mod major
minor - 25 mg/day 1 day moderate 50-75 mg/day 25 mg q 8-12 hours for 1-2 days major- 100-10 mg/day 50 mg q 8-12 hours 2-3 days
29
septic shock dose of hydrocortisone
IV 50 mg q 6 hours | 200 mg/day cont infusion 24 hours
30
dose of hydrocortisone thyroid storm
IV 300 mg LD | 100 mg q 8 hours
31
onset of hydrocortisone
rapid
32
metabolism of hydrocortisone
hepatic
33
half life of hydrocortisone
8-12 hours
34
excretion of hydrocortisone
URINE 17-hydrosteriods 17-ketosteriods
35
Adverse reactions with hydrocortisone
``` MANY imapired wound healing adrenal suppression CV neuro skin cushing's DM hyperglycemia osteoporosis ```
36
contraindications with hydrocortisone
systemic fungal infections serious infections- except septic shock or MB meningitis-viral,fungal, tubercular skin lesions IM with ITTP intrathecal
37
trade name of methylprednisolone
solu-medrol
38
how is methylprednisolone supplied?
125 mg 40 mg 25 mg IV in benzyl alcohol- mix with powder
39
use of methylpredinisolone
``` anti-inflammatory immunosuppressant for: dermatologic endocrine GI hematologic allergic inflammatory neoplastic neurologic opthlamic renal respiratory autoimmune ```
40
what major condition is methylprednisolone used for?
prevention of graft-v-host disease following allogenic bone marrow transplant
41
MOA of corticosteriods
``` decreased inflammation by suppression of migration of PMN leukocytes and reversal of increased capillary permeability tissue-specific regulate gene expression bind specific intracellular receptors translocateion into the nucleus wide array of physiological effects: carb metabolism, protien, and lipid metabolism maintenance of fluid and electrolyte homeostasis CV IMMUNE MSK Edocrine Nerulogic ```
42
dose of methylpredinisolone oral
2-60 mg/day 1-4 days
43
dose of methylpredinisolone IM succinate
10-80 mg/day | once a day
44
dose of methylpredinisolone IM acetate
10-80 mg every 1-2 weeks
45
dose of methylpredinisolone IV
10-40 mg over a period of several minutes repeated IV or IM depending on clinical response 4-6 hours 125 mg for 48 hours
46
onset of methylpredinisolone Oral IM IV intra-aricular
oral 1-2 hours IM 4-8 days IV -rapid IA- 1 week
47
duration of methylprednisolone
30-36 hours oral IM 1-4 weeks IA 1-5 weeks
48
half life of methylpredinisolone
3-3.5 hours | reduced in obesity
49
Adverse Reactions with methylprednisolone
MANY - same as other corticosteriods
50
contraindications of methylprednisolone
``` hypersensitivity to ingredients systemic fungal infections administration of live virus vaccines methylprednisolone formulations containing benzyl alcohol preservatives in premature infants ITTP intrathecal administration ```

Anesthesia Drug Test Quick Facts (19 decks)

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