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Flashcards in Storm Drugs Deck (16):
1

Example of covalent nonselective alpha adrenergic receptor antagonist

Phenoxybenzamine (POB)

2

MOA of phenoxybenzamine

- Blocks alpha adrenergic activation
(both alpha-1 and alpha-2)
--> vasodilation, NE release

3

Example of non-covalent nonselective alpha adrenergic antagonist

Phentolamine

4

MOA of phentolamine

- Blocks alpha adrenergic activation
(both alpha 1 and alpha 2)
--> vasodilation, NE release

5

Example of selective alpha 1 antagonist

- Prazosin
- Terazosin

6

MOA of prazosin

Blocks alpha 1 activation --> vasodilation

7

Example of selective alpha 2 antagonist

Stimulates production of NO
--> vasodilation

8

Example of non-selective beta adrenergic antagonists

- Propranolol
- Timolol
- Nadolol

9

MOA of propranolol

- Blocks beta receptors in the heart
- Decreases CO
- Decreases renin from the kidney

10

Example of beta 1 selective antagonist

- Atenolol
- Metoprolol
- Esmolol

11

MOA of atenolol

Blocks beta 1 activation
--> decreases HR

12

Example of beta 2 selective antagonist

Butozamine

13

MOA of butozamine

Blocks beta 2 activation

14

Example of mixed adrenergic receptor antagonist

Labetalol

15

MOA of lebatolol

- Non-selective beta antagonist
- alpha 1 selective antagonist

16

MOA of a-methyldopa

- converted in nerve terminal to a-methylNE (alpha 2 selective agonist)
- acts in CNS to decrease sympathetic effects