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Flashcards in STS Deck (26)
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1
Q

Most STS occur in middle-aged to older dogs with the exception of

A

rhabdomyosarcoma

2
Q

What is the likelihood of local recurrence for STS after surgery dependent on?

A

tumor size, degree of infiltration, completeness of excision, grade

3
Q

What is the likelihood of metastasis from STS primarily dependent on?

A

Grade

4
Q

What are the symptoms seen with intermuscular lipomas in dogs? (Case JAAHA 2012)

A

lameness, horner’s

5
Q

What was the rate of recurrence for marginally excised intermuscular lipomas? (Case JAAHA 2012)

A

0% during a mean follow up time of 13.5mo

6
Q

Where to 80% of intermuscular lipomas occur on the pelvic limb of dogs? (Case JAAHA 2012)

A

Between the semimembranous and semitendinousus

7
Q

What is the survival time for dogs with lymphangiosarcoma? What improves this? (Curran VCO 2014)

A

Survivals range from 60-941d

Multimodal therapy improves

8
Q

What was the DFI in dogs with incompletely resected STS treated with CTX/piroxicam vs. controls? (Elmslie JVIM 2008)

A

410d treated (13.6mo) vs. 211d (7mo) in controls

9
Q

What was the rate of SHC in dogs treated with metronomic CTX and piroxicam for incompletely excised STS? What was the dose of CTX? (Elmslie JVIM 2008)

A

SHC = 10%

CTX 10mg/m2 PO q24hrs

10
Q

What was the outcome of dogs with high grade STS treated w/ or w/o doxorubicin? (Selting JAVMA 2005)(

A

No difference - no benefit to doxo

11
Q

Neutrophil:lymphocyte in STS was (higher/lower) and albumin:globulin in STS was (higher/lower) than in dog with benign soft tissue tumors (lipomas or fibromas? (Macfarlane JSAP 2016)

What cutoffs were recommended?

A

Neut:lymph higher, alb:glob lower (think inflammation)

neut: lymph >4.5 consistent with STS
alb: glb <1 consistent with STS

12
Q

What marker was expressed in well differentiated and dedifferentiated liposarcomas (vs. not in pleomorphic liposarcomas) and was also found in grade 1 liposarcomas? (Avallone Vet Path 2016)

A

MDM2

13
Q

Hemangiopericytomas had higher _____ compared to PNST (de Queiroz VCO 2012)

A

serum VEGF

14
Q

What is prognostic for tumor recurrence for STS? (Dennis Vet Path 2011)

A

Complete margins predicts nonrecurrence

propensity for recurrence increases with tumor grade

15
Q

What does and what does not correlated with reduced survival time for dogs with STS?

A

High mitotic index prognostic for survival (> 9 = 150-343d, <9 826-1138d)

Metastasis did not equate with poor survival

16
Q

What was the rate of recurrence for marginally or narrowly excised grade I II or III STS? (Dennis Vet Path 2011)

A

I 7% recurrence

II - 35% recurrence

III - 75% recurrence

17
Q

A size of ____ was prognostic for mass recurrence in perivascular wall tumors (Stefanello JVIM 2011)

A

> 5cm

18
Q

What was the MST for dogs twith trigeminal nerve sheath tumors treated with hypofractionated frameless volumetric modulated arc RT? (Dolera VRU 2018)

A

MST 952 d (31.7mo = 2.6yrs)

19
Q

What were the most common clinical signs for dogs with trigeminal nerve sheath tumors? (Swift VRU 2017)

A

masticatory mm atrophy (26/27 dogs, usually unilateral)

neuro signs related to intracranial disease (48%)

ocular disease (85%)

20
Q

What was the MST for dogs with trigeminal nerve sheath tumors treated with SRT vs. no treatment? (Swift VRU

A

SRT 441d (14.7mo)

no treatment 12 d (but wide range)

21
Q

What was the rate of clinical benefit for dogs with macroscopic sts treated with 5x6gy RT? (Cancedda VRU 2016)

A

100% clinical benefit

10% CR, 20% PR, 70%SD

22
Q

Did the addition of metronomic chemotherapy improve survival times for dogs with macroscopic STS treated with 5 x 6gy RT? What was the metronomic chemo protocol? (Cancedda VRU 2016)

A

Metronomic = thalidomide 1-2mg/kg/day, piroxicam 0.3mg/kg/day, CTX 7mg/m2 EOD

OST longer (757 vs. 286) but PFI was not

23
Q

What was the rate of local recurrence and metastasis for dogs with microscopic STS treated with hypofx rt? (6-8Gy weekly fx to 24-32Gy) (Kung VCO 2014)

A

21% local recurrence, 23% met rate

24
Q

What is the MST for dogs with splenic liposarcoma treated with surgery? What was prognostic? (Gower JAVMA 2015)

A

MST 623

Mets = shorter MST (45d)

Grade prognostic

Grade 1 >1009d, grade 2 = 206d, grade 3 = 74d

25
Q

What was the overall rate of metastasis for dogs treated for primary abdominal visceral STS? What was correlated with likelihood of mets? (Linden VCO 2019)

A

overall 40%, 30% at surgery

grade correlated - 20% grade I, 27% gr2, 60%gr 3

26
Q

A mitotic index of ____ was associated with survival post-op for primary abdominal visceral STS in dogs (Linden VCO 2019)

A

MI ≥ 9 = 269d

MI < 9 = MST not reached