Sulfonamides, Trimethoprim, and Fluoroquinolones Flashcards Preview

Pharma > Sulfonamides, Trimethoprim, and Fluoroquinolones > Flashcards

Flashcards in Sulfonamides, Trimethoprim, and Fluoroquinolones Deck (19):
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Folate antagonist

Trimethoprim-sulfamethoxazole

1

Trimethoprim-sulfamethoxazole

Folate antagonist

2

Trimethoprim-sulfamethoxazole

Mechanism of action

Synergistic combination of folate antagonists blocks purine production and nucleic acid synthesis

3

Synergistic combination of folate antagonists blocks purine production and nucleic acid synthesis

Trimethoprim-sulfamethoxazole

Mechanism of action

4

Trimethoprim-sulfamethoxazole

Effects

Bactericidal activity against susceptible bacteria

5

Trimethoprim-sulfamethoxazole

Clinical applications

Urinary tract infections, P jiroveci pneumonia, toxoplasmosis, nocardiosis

6

Urinary tract infections, P jiroveci pneumonia, toxoplasmosis, nocardiosis

Trimethoprim-sulfamethoxazole

Clinical applications

7

Fluoroquinolones

Ciprofloxacin
Ofloxacin
Levofloxacin
Moxifloxacin
Gemifloxacin

8

Ciprofloxacin
Ofloxacin
Levofloxacin
Moxifloxacin
Gemifloxacin

Fluoroquinolones

9

Ciprofloxacin
(fluoroquinolones)

Mechanism of action

Inhibits DNA replication by binding to DNA gyrase and topoisomerase IV

10

Fluoroquinolones

Ciprofloxacin
(fluoroquinolones)

Mechanism of action

11

Ciprofloxacin
(fluoroquinolones)

Effects

Bactericidal activity against susceptible bacteria

12

Bactericidal activity against susceptible bacteria

Ciprofloxacin
(fluoroquinolones)

Effects

13

Ciprofloxacin
(fluoroquinolones)


Clinical applications

Urinary tract infections, gastroenteritis, osteomyelitis, anthrax

14

Urinary tract infections, gastroenteritis, osteomyelitis, anthrax

Ciprofloxacin
(fluoroquinolones)


Clinical applications

15

Ofloxacin

Oral; has improved pharmacokinetics and pharmacodynamics; use is limited to urinary tract infections and nongonococcal urethritis and cervicitis

16

Oral; has improved pharmacokinetics and pharmacodynamics; use is limited to urinary tract infections and nongonococcal urethritis and cervicitis

Ofloxacin

17

Levofloxacin

Oral, IV; L-isomer of ofloxacin; once-daily dosing; renal clearance; "respiratory" fluoroquinolone with improved activity versus pneumococcus

18

Oral; has improved pharmacokinetics and pharmacodynamics; use is limited to urinary tract infections and nongonococcal urethritis and cervicitis

Levofloxacin