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Ashley CDE Exam > Sulfonylureas > Flashcards

Flashcards in Sulfonylureas Deck (16):
1

Do you need and endogenous insulin to use a sulf medication

Yes, sulfonylurea agents are useful only in patients who still produce endogenous insulin, they are exclusively for type 2 diabetics

2

Who is the typical candidate for a monotherapy with sulfonylurea

Type 2 diabetic without dyslipidemia who is not overweight

3

What is the mechanism of action for sulfonylurea

Increase the release of insulin from the pancreas by closing the energy sensitive potassium channel in the cell membrane of the beta cells which causes an increase in available insulin for action throughout the body

4

What two organs must you be cautious of when taking a sulfonylurea

Liver because that is where it is processed in metabolize, and renal

5

How do you do dose a sulfonylurea

Started at low doses and titrated as needed ranging from 1-8 milligrams daily

6

What are the names of the second generation sulfonylurea groups

Glimepiride (amaryl), glipizide (glucotrol), glyburide (diabeta, micronase)

7

What is the name for glimipiride

Amaryl

8

What is the name for glipizide

Glucotrol

9

What is the name for glyburide

Diabeta
Micronase
Glynase

10

How are sulfonylureas classified

category C, although wipe your eyes in retrospective studies although because many drugs are excreted in human milk so familiar areas should not be administered during nursing

11

Can you use sulfonylurea in children

Safety has not been established in children

12

Who should be monitored when taking a sulfonylurea

Elderly, debilitated, malnourished, adrenal pituitary or hepatic insufficiency, hypoglycemic patient

13

What are contraindications for sulfonylurea

Type 1 diabetics, ketoacidosis, allergy, hypersensitivity

14

What is the most common and serious adverse reaction to sulfonylurea

Hypoglycemia

15

What effects does sulfonylurea have on the blood sugars of the elderly

Progressive age related to clean and renal function alters drug clearance and predisposes a person to hypoglycemia

16

Does weight gain occur with sulfonylurea

Yes to the increase in insulin secretion