Summary of Kidney in Systemic Disease II Flashcards Preview

Renal Week 3 > Summary of Kidney in Systemic Disease II > Flashcards

Flashcards in Summary of Kidney in Systemic Disease II Deck (5):

Sickle cell nephropathy
• Prevalence in Sickle cell pts.
• Style of damage?

4 to 12% of patients with hgb SS disease will develop end-stage renal disease (ESRD)

Associated with glomerular enlargement and focal segmental glomerulosclerosis


• Strongest association you should make?
• Location?
• Proliferation?
• Inflammation?

• this is a NON-INFLAMMATORY renal disease that is located in EXTRACELLULAR SPACES and does NOT involve cell proliferation

• Ironically CHRONIC INFLAMMATION is the most common cause of this disease


Light Chain Disease
• Amyloid?
• Staining?
• Disease association?

• nonamyloid monoclonal immunoglobulin deposition disease
• Congo red negative
• Involves precipitation of immunoglobulin chains without the elongation seen in amyloid
• Usually associated with multiple myeloma


HIV-associated nephropathy
• Edema?
• Type of Renal Damage?

• Progressive azotemia, significant proteinuria and MINIMAL PERIPHERAL EDEMA (weird for a protein loss)

• Collapsing focal segmental glomerulosclerosis with pronounced MICROCYSTIC tubular dilation, interstitial inflammation, and fibrosis

***Nephrotic w/o looking nephrotic
Collapsing doesn’t mean they have to be HIV+***


• Disease Association?
• Pattern of Injury?
• Location of injury?

• Associated with Hepatitis C in more than 90% of cases

• Deposition of immune complexes containing rheumatoid factor (RF), IgG, HCV RNA, and complement on endothelial surfaces

• Causes a membranoproliferative pattern of injury