Flashcards in Summary of Kidney in Systemic Disease II Deck (5):
Sickle cell nephropathy
• Prevalence in Sickle cell pts.
• Style of damage?
4 to 12% of patients with hgb SS disease will develop end-stage renal disease (ESRD)
Associated with glomerular enlargement and focal segmental glomerulosclerosis
• Strongest association you should make?
• this is a NON-INFLAMMATORY renal disease that is located in EXTRACELLULAR SPACES and does NOT involve cell proliferation
• Ironically CHRONIC INFLAMMATION is the most common cause of this disease
Light Chain Disease
• Disease association?
• nonamyloid monoclonal immunoglobulin deposition disease
• Congo red negative
• Involves precipitation of immunoglobulin chains without the elongation seen in amyloid
• Usually associated with multiple myeloma
• Type of Renal Damage?
• Progressive azotemia, significant proteinuria and MINIMAL PERIPHERAL EDEMA (weird for a protein loss)
• Collapsing focal segmental glomerulosclerosis with pronounced MICROCYSTIC tubular dilation, interstitial inflammation, and fibrosis
***Nephrotic w/o looking nephrotic
Collapsing doesn’t mean they have to be HIV+***