Sweatman Bladder Cancer and Ovarian Cancer Flashcards Preview

Reproductive > Sweatman Bladder Cancer and Ovarian Cancer > Flashcards

Flashcards in Sweatman Bladder Cancer and Ovarian Cancer Deck (36):
1

serum marker used to monitor the course (activity/progression) of ovarian cancer

CA 125
--> not very good diagnostically

2

unique mode of delivery of drug available for ovarian cancer with peritoneal seeding

IntraPeritoneal instillations
_decrease rate of buildup of the ascites

3

first options for ovarian cancer with/without seeding

High volume IP cisplatin

4

IP admin benefits

allows higher dose
-more frequent administration
-appears more effective

5

adjuvant therapy following cisplatin
STAGE 1 and 2
(confined to one or both ovaries/ spread to pelvis)

IV Carboplatin/cisplatin

include Cyclophosphamide
and or Doxorubicin

6

Adjuvant therapy stage 3-4

IV carboplatin/cisplatin with paclitaxel

7

targetted therapies for ovarian CA

none

8

Administration of IP dosing

-only for locally confined disease
-> 1-2 L retained for 2 hours then drained off
-pateint supine rotated from side to side to ensure adequate coverage

9

bladder cancer mutations

FGFR3
HRAS
Chromosome 9 (with a shit tone of shit)

10

highest risk factor for developing bladder cancer

long history of smoking

11

most common presenting symptom of bladder cancer

hematuria
*likely microscopic not gross)

12

main cell type incolved in 70% of bladder cancers

urothelial
70% are superficial on presentation

13

drugs most commonly used for intravesical instillation

Mitomycin
BCG
Thiotepa (less common)

14

progression of therapy in Bladder cancer pt.'s

1. TURBC
2. Intravessicular Mitomycin/ IVe BCG/other
3. Chemo-radiation or systemic therapy
4. cystectomy

15

activity of BCG requires

intact immune system

16

MOA for BCG (bacillus calmette Guerin)

Binds urothelium, activates APC's, Induces host CTLs, NK's, AK,'s, BAK's
>for 6 weeks
>immune response detected wihtin hours and lassts for days

17

lipophillic small MW drug that can penetrate urothelial tissue

Thiotepa

18

most drugs in tx of bladder cancer are....

alkylating agents

19

forms DNA intrastrand corss links

Cisplatin and Carboplatin

20

Pro-Drug of alkylating moiety

Cyclophosphamide

21

intercolator, free radical generator and topo II inhibitor

Doxorubicin

22

Mono and Bi functional alkylating agents

mitomycin C

23

microtubule stabilizer inhibiting depolymerization

Paclitaxel

24

polyfunctional alkylator with loss of aziridine moeity

Thiotepa
remaininig moeity forms DNA cross links

25

nephrotoxicity

cisplatin

26

ototoxicity (tinnitis and occasional defaness)

cisplatin

27

dose limiting myelosupression

cisplatin and carboplatin
doxorubicin

28

hemorrhagic cysititis, anemia/infection, amenorrhea/infertility,

cyclophosphamide

29

monitor for secondayr malignancies

cyclophosphamide
doxorubicin

30

Blood dyscrasias

cyclophosphamide

31

mesna is protective

cyclophosphamide

32

CHF

doxorubicin

33

extravasational necrosis

doxorubicin

34

IVe issues with Mitomycin

-chemical cystitis
-dermatitis & palmar/plantar erythema

35

IVe issues with Thiotepa

dysuria, urinary retention, chemical/hemorrhagic cystitis

36

IVe drug also capable of causing pulmonary infiltrates, Dyspnea, dry cough

Mitomycin