Sx/ Anesthesia opioids

Question 1

which of the followinf it TRUE concerning the Opioid receptors subtype
A. The mu receptor is associated with the highest quality of analgesia
B. Clinically used opioids may be an agonist at one r

Question 2

Although opioids and alpha 2 agonist drugs both produce sedation and analgesia there are differences. Which of the following is true concerning opioids or A2 agonist drugs at clinical dosages?
A. A2 agonist associated w profound resp depression
B. A2 agonist are associated w profound muscle relaxation
C. Opioids are associated w profound muscle relaxation
D. None of the above

Answer 2

B. A2 agonist are associated w profound muscle relaxation (xylazine. dex)

high dose of fentanyl increase muscle tone

Question 3

Which of the following is true concerning administration of epidural opioids?
A. epidural administration of hydrophilic opioids such as morphine is long term duration
B. of opioids produces analgesia by binding to A2 adrenoreceptors in spinal cord ventral horn
C epidural admin of opioid does not carry a risk of resp depression
D. epidural admin of opioid is accomplished by injection into the L3-L4 intrathecal space

Answer 3

(A) hydrophilic opioids are long term effects, lipophilic is short term

Notes:
C- does carry risk if carried rostral to brain stem

Question 4

Which of the following is true about the opioid Meperidine?
A. increase heart rate
B. decrease cardiac contractility
C. mu opioid receptor agonist
D. all of above

Answer 4

Correct: D

Notes:
Chemical structure- nothing like morphine
soul exception that opioid will not do

Question 5

An agonist/antagonist opioid drug....
A. does not cross the placenta
B. binds to only 1 opioid receptor subtype
C. has no sedative effects
D. none of the above are true 

(give example)

Answer 5

D none of the above.

butorphanol - k agonist / mu antagonist

Question 6

Opioid receptor to primary effect
A. Buprenorphine: K
B: Methadone: Delta
C. Hydromorphone: mu 
D. Naltrexone: sigma

Answer 6

C:
A. delta, mu partial agonist, k ant
B.mu
C. mu
D. antagonist (longer lasting than naloxone)

Question 7

Iv administration of what opioid is frequently associated with histamine release and resultant hypotension?

Answer 7

Correct: morphine

stable cardiovascular drugs:

• Fentanyl
• methadone
• butorphanol

Question 8

opioid with the longest duration of action following IM injection?

Answer 8

Buprenorphine

Question 9

butorphanol short or long lasting drug?

Answer 9

short lasting

Question 10

what opioid has longest duration of action

Answer 10

buprenorphine

Question 11

In dogs what opioid are we most likely to use?

Answer 11

Mu receptor agonist

Question 12

Administration of what opioid is associated with the lowest incidence of CNS excitation in horses.

Answer 12

Butorphanol