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Flashcards in Sympathomimetics Deck (20):
0

MOA of sympathomimetics

Direct activation of adrenoceptors
Releases stored catecholamines
Inhibits catecholamines reuptake

1

Non-selective, direct acting, sympathomimetics

Epinephrine, norepinephrine, dopamine,

2

Epinephrine

Activates a and b receptors
a1 - vasoconstrictor increases BP by increasing TPR
b1 - increased HR, conduction, contractility
b2 - bronchodilator

3

Norepinephrine

Activates a and b receptors
a1 - vasoconstrictor increases BP by increasing TPR
b1 - increased HR, conduction, contractility
b2 - bronchodilator

4

Dopamine

Activates a and b and D receptors
a1 - vasoconstrictor increases BP
b1 - increased HR, conduction, contractility
D1 - vasodilation in splanchnic and renal vessels

5

Low dose epinephrine 1-5 mcg

Renal/splanchnic vasodilation by D1 RECEPTORS

6

Medium dose 5-15 mcg

Inotropic. Heart rate and cardiac contractility via BETA RECEPTORS

7

High dose >15 mcg

Vasoconstrictor increased BP alpha receptors

8

Sympathomimetics beta-non selective

Isoproterenol
Activates b receptors
b1 - increased HR, conduction, contractility
b2 - bronchodilator

9

Selective alpha 1 antagonist

Phenylephrine/ pseudophedrine
a1 - vasoconstrictor, increases BP
WOF rebound nasal congestion
Mydriasis without psychoplegia

10

Selective a2 agonist

Clonidine, methyldopa, apraclonidine

11

Clonidine

a2 - decreases central sympathetic outflow
WOF for rebound hypertension give PHENTOLAMINE as antidote

12

Methyldopa

a2 - decreases central sympathetic outflow esp. Pre-eclampsia
WOF hemolytic anemia (+) Coomb's test

13

Apraclonidine

a2 - decreases secretion of aqueous humor.
BRIMONIDINE

14

Selective beta1 agonist

Dobutamine b1 - increases HR and contractility
Use in acute heart failure

15

Selective b2 - agonist

Albuterol/salbutamol, terbutaline, ritodrine
Activates b2 receptors in bronchial smooth muscles, causes bronchodilation,
TR can be used for preterm labor

16

Acute heart failure, septic shock

b1 and D1 agonist
to raise cardiac output

17

Hemostasis, decongestant, spinal shock

a1 agonist
Causes vasoconstriction, temporary maintenance of BP

18

Bronchospasm
Premature labor

b2 agonist,
bronchodilation and relaxation of uterine smooth muscle

19

Hypertension
Glaucoma

a2 agonist
Decreases BP