synaptic transmission I

Question 1

steps of synaptic transmission?

Answer 1

1. transmitter is synthesized and stored in vesicles
2. action potential invades the presynaptic terminal
3. depolarization of presynaptic terminal causes opening of voltage-gated Ca2+ channels
4. influx of Ca2+ through channels
5. Ca2+ causes vesicles to fuse with presynaptic membrane
6. transmitter is released into synaptic cleft via exocytosis
7. transmitter binds to receptor molecules in postsynaptic membranes
8. opening or closing of postsynaptic channels
9. postsynaptic current causes excitatory or inhibitory postsynaptic potential that changes the excitability of the postsynaptic cell
10. removal of neurotransmitter by glial uptake or enzymatic degradation
11. retrieval of vesicular membrane from plasma membrane