Synthesis Flashcards

1
Q

Carbonyl -> hydroxynitrile

A

Cyanide ion
NaCN +H2SO4 ->HCN
reflux, alkaline solution
Nucleophilic addition

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2
Q

Haloalkane -> nitrile

A

Cyanide ion
KCN
Reflux
Nucleophilic substitution

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3
Q

Benzene alkylation

A

Haloalkane + AlCl3 catalyst
room temp, dry inert solvent
electrophilic substitution

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4
Q

Benzene acylation

A

Acyl chloride + AlCl3 catalyst
reflux, 50’C, dry inert solvent
electrophilic substitution

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5
Q

product of acylation of benzene

A

Phenylketone

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6
Q

Reduction of nitriles

A

nitrile +2H2 -> amine

Ni catalyst

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7
Q

Acid hydrolysis of nitrile

A

nitrile + 2H2O + HCl -> carboxylic acid + NH4Cl

HCl is dilute/aqueous

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