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Micro Exam VI > SyphilisInfections > Flashcards

Flashcards in SyphilisInfections Deck (35):
1

How does syphilis infection begin:

With usually ONE, PAINLESS INDURATED lesion at the point of entry (genital ulcer)

2

Secondary syphilis manifestation:

Maculopapular rash

3

Maculopapular rash of secondary syphilis enters what phase if untreated:

latency phase - which may be CLEARED by the immune system

4

If latency stage of syphilis is not cleared by the immune system:

It may reappear as tertiary syphilis years to decades later.

5

How many people are infected with syphilis in the US per year?

50,000

6

Causative agent of Syphilis:

Treponema Pallidum

7

**Features of Treponema Pallidum:

Gram (-) spirochete, Motile, Microaerophilic, Have flexible peptidoglycan wall

8

Culturing Treponema Pallidum

Does not grow in cell free culture. Very difficult to grow in cell culture

9

Why can Treponema Pallidum not be seen with light microscopy:

The spirochetes are too thin. GRAM STAINING NOT RECOMMENDED

10

Two diagnostic techniques for Treponema Pallidum:

Dark field microscopy or Direct Fluorescent Antibody Test.

11

Transmission of Treponema Pallidum:

Sexual contact or congenital

12

Treponema Pallidum infection has a higher incidence in what patient demographic:

MSM

13

**Characteristics of Primary Syphilis

USUALLY ONE skin lesion (chancre) at site where spirochete penetrated. This lesion is PAINLESS AND INDURATED.

14

**Secondary syphilis onset time:

2-8 weeks post chancre

15

**Presentation of Secondary Syphilis:

*Flu-like syndrome. Prominent skin lesions dispersed over the entire body including PALMS and SOLES. Condyloma lata may occur, also.

16

**Condyloma Lata:

Raised lesions in skin folds that have a soft, flat, moist, pink-tan papule/nodule appearance. Occur with secondary syphilis or congenital syphilis.

17

Characteristics of Latent Syphilis:

It is an asymptomatic period with continued infection. Transmission is still possible.

18

What percent of untreated syphilis patients will proceed to tertiary/late syphilis?

33%

19

Result of tertiary syphilis:

Can cause devastating destruction of virtually any organ or tissue (arteritis, dementia, blindness)

20

Gummas:

Granulomatous Lesions may be found in bone, skin and other tissues. Present in tertiary/late syphilis-presenting patient.

21

Case Presentation of Neurosyphilis:

Progressive cognitive decline and behavioral changes over 18 months. Testing revealed impaired memory and attention along with mild to moderate dementia and executive dysfunction.

22

Treatment of Neurosyphilis:

High-dose IV penicillin

23

Tuskegee Syphilis importance:

beginning of informed consent for research subjects and much information garnered about tertiary syphilis

24

Mothers with Syphilis have risk of:

transmission to fetus resulting in fetal loss or congenital syphilis

25

Features of Congenital Syphilis that develop after birth:

Rhinitis (leads to saddle nose), Maculopapular Rash, Condyloma Lata (around mouth often in infants)

26

Additional Features of Congenital Syphilis that develop:

Teeth (Hutchinson's teeth) and bone deformation, Blindness, Deafness, Cardiovascular Syphilis

27

Most common diagnostic test for Syphilis:

Antibody detection/serology

28

Nontreponemal Test used for Syphilis diagnosis:

Measured antibody directed against cardiolipin (lipid complex)

29

Treponemal Test used for Syphilis diagnosis:

Detect antibody SPECIFIC to Treponema Pallidum

30

Treatment of Syphilis:

Penicillin

31

Hutchinson's Triad:

blunted teeth, blindness, deafness (hallmark of **congenital syphilis** infections)

32

Examples of Nontreponemal Tests for Syphilis Diagnosis:

Rapid Plasma Reagin (RPR) and Venereal Disease Research Laboratory (VDRL)

33

Examples of Treponemal Tests for Syphilis Diagnosis:

Fluorescent treponemal antibody + Microhemagglutination

34

Person infected with Syphilis will have a positive Treponemal and Nontreponemal test when:

Throughout UNTREATED infection

35

Person once treated for Syphilis will respond how to Treponemal and Nontreponemal test:

Negative Nontreponemal. Positive Treponemal.