Systemic Features of Chronic Inflammation Flashcards Preview

Pathology -- Gen Path > Systemic Features of Chronic Inflammation > Flashcards

Flashcards in Systemic Features of Chronic Inflammation Deck (12):
1

Principle mediators of increased vascular permeability

Histamine, Serotonin, Bradyinin
C3a, C5a, PAF, SRS-Ss
IL-1, PGs

2

Primary mediator of increased BF

Prostaglandins (Prostacyclin, Bradykinin)

3

Cause of increased ESR with inflammation?

Increased fibrinogen as an acute phase protein

4

One common factor to different cases of amyloidosis?

Presence of very distinctive extracellular fibrils called b-pleated sheets

5

Unusual cell type that pops up in leukocytosis?

band cells
Caused by dumping PMNs as they are developing due to CSF release

6

Approach to block activation of inflammatory cells?

Steroids

7

Approach to inhibit formation of 2ndary messengers

Epinephrine, beta-agonists

8

Approach to inhibit formation of mediators

COX inhibitors
Lipoxygenase inhibitors

9

Approach to block receptors on target tissues

Antihistamines (H1/H2)
Anti-integrins
Leukotriene antagonists

10

Approach to block physiological effects of inflammation

Mechanical measures

11

Important Aspirin details

Irreversible inhibition of COX
Low dose inhibits thromboxane. higher inhibs. prostacyclin
Side effect -- gastric eroisions

12

Name LT inhibitors..

Montelukast
Zafirlukast