Flashcards in Systemic Features of Chronic Inflammation Deck (12):
Principle mediators of increased vascular permeability
Histamine, Serotonin, Bradyinin
C3a, C5a, PAF, SRS-Ss
Primary mediator of increased BF
Prostaglandins (Prostacyclin, Bradykinin)
Cause of increased ESR with inflammation?
Increased fibrinogen as an acute phase protein
One common factor to different cases of amyloidosis?
Presence of very distinctive extracellular fibrils called b-pleated sheets
Unusual cell type that pops up in leukocytosis?
Caused by dumping PMNs as they are developing due to CSF release
Approach to block activation of inflammatory cells?
Approach to inhibit formation of 2ndary messengers
Approach to inhibit formation of mediators
Approach to block receptors on target tissues
Approach to block physiological effects of inflammation
Important Aspirin details
Irreversible inhibition of COX
Low dose inhibits thromboxane. higher inhibs. prostacyclin
Side effect -- gastric eroisions