Flashcards in Systemic Spirochetes Deck (8):
What are spirochetes and what are there three major genera?
Spiral shaped organisms with corkscrew motility that grow slowly in vitro and do not gram stain.
Treponema, Borrelia, and Leptospira
What do you know about Treponema spirochetes?
All agents produce the same serological response in humans
Susceptible to penicillin
What do you know about Borrelia spirochetes?
Borrelia burgdorferi causes Lyme disease, B. Recurrentis causes louse born recurring endemic fever
B. hermsii causes tick born endemic relapsing fever
What do you know about Lyme disease?
Tick born (Ixodes)
Transmitted in nymph stage
What are the three clinical stages of Lyme disease?
Stage 1 is localized infection causing erythema migrans
Stage 2 is disseminated infection causing carditis, secondary erythema migrans, meningitis, bells palsy, and arthritis.
Stage 3 is persistent infection causing arthritis and lyme encephalopathy.
What is the definitive test for lyme disease?
Two-tiered testing with ELIZA and Western Blot.
Lab testing will be negative if conducted early in the infection
What is STARI
Southern Tick Associated Rash Illness: a lyme disease like illness spread by the lone star tick