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Immunology Exam #2 > T Cell Regulation > Flashcards

Flashcards in T Cell Regulation Deck (31)
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1

what is the overall purpose of T reg cells

restrain the immune system

2

in the presence of what cytokine will a t cell become a T reg cell

TGFbeta

3

activated helper T cells secrete which cytokines to activate the immune system

TNF and IFN-y

4

activated T reg Cells secrete which cytokines to restrain the immune system

TFGbeta and IL-10

5

what does TFGbeta stand for

transforming growth factor beta

6

what does TFGbeta do

-binds to receptors on T cells
-reduces proliferation
-reduces CTL killing

7

what does IL-10 do

-binds to receptors on T cells
-blocks co-stim signals (CD28)
-reduces proliferation

8

does the intestines produce TGFbeta

yes (the epithelial cells)

9

TFGbeta does what in the Peyers Patch

causes T cells to become T reg cells

10

what do T reg cells do in the GI tract

encourage a calmer mucosal immune system

11

T/F T reg cells prevent allergies

true

12

For co-stim does the APC present the B7 or CD28

B7

13

what do very experienced T cells make more and more of

CTLA-4

14

what does CTLA-4 do

-binds to B7 and blocks CD28
-out competes CD28

15

what does CTLA-4 have very difficult for the T cell to do

become activated

16

what does PD1 stand for

Programmed Death 1 receptor

17

which cells express PD1

activated T cells

18

which cells express PD1-L

WBCs and inflamed tissue

19

what does the engagement of PD1 and PD1-L do

slows proliferation of T cells and may induce apoptosis

20

what is another name for the PD1-L

the down regulator

21

T/F any cell that expresses the PD1 receptor can be down regulated

true

22

T/F once activated, T cell longevity is greatly enhance

False

23

what does AICD stand for

Activation-Induced Cell Death

24

explain AICD

-older T cells Fas proteins become sensative
-Fas Ligand and Fas proteins on SAME cell can engage (apoptosis)
-Fas proteins from a younger T cell can engage Fas Ligand on an older T Cells and kill the older T cell

25

Does CTLA-4 have a stronger affinity for B7 than CD28

yes, 1000X the affinity

26

What is the lifespan of a Neutrophil

few days

27

what is the lifespan of a NKC

1-2 wks

28

what is the lifespan of a macrophage

months (but needs continual activation)

29

what is the lifespan of a DC

wks (after reaching a lymph node)

30

what is the life span of a Plasma B cell

5 days of making 2,000 Ab a day