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Flashcards in TCA cycle Deck (16):
1

where does the TCA cycle occur?

mitochondria

2

is the TCA cycle aerobic or anaerobic?

Aerobic

3

what are the 5 coenzymes of pyruvate dehydrogenase and the alpha-ketoglutarate dehydrogenase complex ?

NAD+
FAD
Coenzyme A
LIpoic acid
Thiamine pyrophosphate (TPP)

4

what are the activators of pyruvate dehydrogenase?

pyruvate
NAD+
ADP
Ca2+
CoA

5

What are the deactivators of pyruvate dehydrogenase?

acetyl CoA
NADH
ATP

6

what are the activators of isocitrate dehydrogenase?

ADP
Ca2+

7

what are the inhibitors of isocitrate dehydrogenase?

ATP
NADH

8

what are the activators for alpha-ketoglutarate dehydrogenase?

Ca2+

9

what are the deactivators for alpha-ketoglutarate?

NADH
Succinyl- CoA

10

how many ATP are generated from 1 acetyl CoA per TCA cycle?

12

11

what is the total amount of energy (ATP) that theoretically can be gained from 1 molecule of glucose that cycles through the body?

38 ATP

12

what are the 2 key enzymes in TCA that are inhibited in arsenic poisoning?

PDH
alpha-ketoglutarate dehydrogenase

13

what is Wernicke- Korsakoff syndrome?

encephalopathy psychosis caused by a deficiency in thiamine

14

what population is Wernicke-Korsakoff often seen in ?

chronic alcoholics

15

what deficiency can cause Leigh syndrome?

PDH

16

what are the symptoms of Leigh syndrome?

chronic lactic acidosis
neurodegeneration
muscle spasticity
early death
brain damage