Test 2 Zita 2018 Flashcards Preview

Pharmacology 2 Past Qu. > Test 2 Zita 2018 > Flashcards

Flashcards in Test 2 Zita 2018 Deck (12):
1

Inhibitors of CYP450?

Macrolides Ab, Sulphonamides, Plants, Omeprazole, Tiamulin, Cimetidine.

2

Phase I (Goals) + 4 enzymes?

Oxidation.
Enzymatic reactions catalysed by microsomal + non-microsomal enzymes.
CYP450 monooxygenases, Monoamine oxidases, Flavin monooxygenases, Alcohol/ Aldehyde dehydrogenases.

3

Centiofur (gen) + what disease (min 4).

3rd generation of Cephalosporins.
GI problems by E coli, Respiratory diseases by fastidious bacteria, Systemic infections in Ru + Eq + Sus, Salmonella.

4

Narrow Spectrum penicillin + 4 diseases.

Inhibit cell wall synthesis, Gram +ve + -ve bacteria.
Respiratory infections, Sus erysipelax, Anthrax, Tetany, Mastitis + Metritis, Strep (strangles).

5

Clavulinic acid, what is it + what to combine with?

ß lactamse inhibitor.
Amoxicilin.

6

How do Cephalosporins work?

Inhibit cell wall synthesis by inhibiting of synthesis of peptidoglycan structure.

7

Enzymes of Phase I.

CYP450 monooxygenases, Flavin monooxygenases, Monoamine oxidases, Alcohol/Aldehyde dehydrogenases.

8

Induces of CYP450?

Toxic substances, Drugs, Plants(cabbage, alkaloid).

9

Cephalosporin given orally + for what?

Cephalexin.
Dermatitis.

10

What is special about Cefovecin + for what is it for?

Long acting ( long half-life), 1 inj lasts for 2 weeks, for aggressive animals.
UTI, Oral Cavity Infection, Gingivitis, Skin Infection.

11

Which Bakterin use ab ovo resistant against ß lactamse?

E.coli, Salmonella, Kelbsiella, Pseudomonas aeruginosa.

12

Spectrum of penicillins?

Narrow, Broad, Penicillinase stable.