Flashcards in Test 2 Zita 2018 Deck (12):
Inhibitors of CYP450?
Macrolides Ab, Sulphonamides, Plants, Omeprazole, Tiamulin, Cimetidine.
Phase I (Goals) + 4 enzymes?
Enzymatic reactions catalysed by microsomal + non-microsomal enzymes.
CYP450 monooxygenases, Monoamine oxidases, Flavin monooxygenases, Alcohol/ Aldehyde dehydrogenases.
Centiofur (gen) + what disease (min 4).
3rd generation of Cephalosporins.
GI problems by E coli, Respiratory diseases by fastidious bacteria, Systemic infections in Ru + Eq + Sus, Salmonella.
Narrow Spectrum penicillin + 4 diseases.
Inhibit cell wall synthesis, Gram +ve + -ve bacteria.
Respiratory infections, Sus erysipelax, Anthrax, Tetany, Mastitis + Metritis, Strep (strangles).
Clavulinic acid, what is it + what to combine with?
ß lactamse inhibitor.
How do Cephalosporins work?
Inhibit cell wall synthesis by inhibiting of synthesis of peptidoglycan structure.
Enzymes of Phase I.
CYP450 monooxygenases, Flavin monooxygenases, Monoamine oxidases, Alcohol/Aldehyde dehydrogenases.
Induces of CYP450?
Toxic substances, Drugs, Plants(cabbage, alkaloid).
Cephalosporin given orally + for what?
What is special about Cefovecin + for what is it for?
Long acting ( long half-life), 1 inj lasts for 2 weeks, for aggressive animals.
UTI, Oral Cavity Infection, Gingivitis, Skin Infection.
Which Bakterin use ab ovo resistant against ß lactamse?
E.coli, Salmonella, Kelbsiella, Pseudomonas aeruginosa.