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Flashcards in Test 47 Deck (62):
1

one week after surgery a liver tx pt develops a SKIN RASH and bloody diarrhea

GVHD

2

commonly occurs after allogenic bone marrow transplant and organs rich in lymphocytes (like hte liver) or the transfusion of non-radiated blood

GVHD

3

T lymphocytes of donor tissue are sensitized against MHC Ag of recipient

skin, liver, intestine most commonly involved

GVHD

4

weakness of muscles and EOM> ptosis and diplopiam

MG

5

majority of pts w/ MG commonly have....

thymoma or thymic hyperplasia

6

associated w/ 3rd pharyngeal pouch

thymus and inferior PTH glands

7

Lamotrigine

blocks VG Na channels

8

SE of Lamotrigine

SJS
toxic epidermal necrolysis


flu like sxs followed by widespread mucocutaneous epidermal necrosis

9

SNS innervation of adrenal and sweat glands

cholingergic fibers

10

SNS innervation to viscera/target organs

noradrenergic (NE)

11

what makes eukaryotic DNA synthesis quick and effective despite the large genome compared to prokaryotic

multiple origins of replicaiton

12

incrased activity of what enzyme is most liekly to promote recurrrent adenoma devleopment?

cox 2

13

lowers incidence of adenomas

aspirin

14

why do women develop gallstones during pregnancy?

estrongen--> increases cholesterol syntehsis by upregulating HMG-CoA--> bile to become supersaturated w/ cholesterol

progesterone--> reduces bile acid secretion and slows gallbladder emptying

15

what is responsible for increased incidence of cholelithiasis in women who are pregnant/using OCPs?

estrogen induced cholesterol hypersecretion

progesterone induced GB hypomotility

16

what replaces infarcted CNS tissue?

cystic astroglial scar

17

abnormal Rinne test in affected ear and Weber test localizes to affected ear

conductive hearing loss

(bone conduction> air conduction)

18

normal Rinne, Weber localizes to unaffected ear

sensorineural

(air conduction > bone conduction)

19

normal Rinne, Weber localizes to unaffected ear

sensorineural

(air conduction > bone conduction)

20

Rinne test

Compares vibrating tuning fork on mastoid bone vs. external ear

Air conducted sound is normally LOUDER nad longer heard than bone conducted sound

21

postive rinne test

NORMAL

sound is heard best at EAM

22

abnormal Rinne

pt hears vibration better at mastoid

conductive hearing loss

23

Weber test

vibrating tuning fork on middle of forehead

24

conductive hearling loss weber test

latearlization to AFFECTED ear> conduction masks the ambient nose in the room> vibraton to be better heard

25

conductive hearing loss weber test

lateralizaiton to unaffected ear> unimpaired ear can better sense vibration

26

PSGN lab findings

elevated ASO/DNAse B
Decreased C3 and total complement
cryoglobulins present

27

serum anti-GBM Abs
Cresent formation

Good pasture syndrome

28

anti-phospholipid Abs

SLE

29

marker for mast cell activation

tryptase

30

marker for mast cell activation

tryptase

31

what causes mast cells to degranulate?

cross linkin gof membrane bound IgE Abs to specific Ag> IgE-Fc receptor AGGREGATON on cell surace

32

pol gene mutations

resistance to HIV RT inhibitors and HIV protease inhibitors

33

Env gene mutations

escape from host neutralizing Abs

34

mechanism most responsible for antiseptic properties of isopropanol?

disruption of cell membranes

35

chlorhexidine

disrupt cell membanres
coagulation of cytoplasm

36

hydrogen peroxide

produces free radicals that oxidize cell components

37

iodine

halogenation of proteins and nucleic acids

38

agent of choice for hyptertensive emergency

nitroprusside

39

major SE of nitroprusside

metabolized to cynaide> cyanide toxicity

40

used to tx cyangide toxicity

Sodium thioSULFATE

donates sulfur to liver rhodanase to enhance conversion of cyanide to thiocyanate

41

used to tx cyangide toxicity

Sodium thioSULFATE

donates sulfur to liver rhodanase to enhance conversion of cyaide to thiocyanate

42

affect of cholinergic agonists on endothelial cells

bind to muscarinic receptors>
release of NO>
increased GC>
decreased Ca concentration>
vasodilation

43

nursemaids elbow

suddent tarction on outstretched pronated arm> torn ANNULAR LIGAMENT

44

gag gene

p24
p7

45

env gene

gp120
gp41

46

tat/rev

required for viral replication

47

Calcium channel blocker used in HTN that can lead to flushing and peripheral edema

Amlodipine

48

Doxazosin
Prazosin
Terazosin

alpha 1 blockers

HYPOtension when first start treatment

49

Propranolol

nonselective B blocker

exacerabte bronchial asthma
peripheral vascular disease
bradycardia

50

drug can mask hypoglycemic sxs of diabetics

propranolol/nonselective beta blockers

51

drug can mask hypoglycemic sxs of diabetics

propranolol/nonselective beta blockers

52

Ramipril

ACE-I

cough
hyperkalemia
angioedema

53

HCTZ

first line med for HTN

diuretic

54

Eplerenone

Aldosterone antag

gynecomastia

55

Verapimil

constipation
gingival hyperplasia

56

Renal failure
pulmonary sxs
upper RT sxs

crescents on light microscopy

ANCA assoc RPGN

abscence of Ig and C3 deposits

57

RPGN w/ NO Ig/C3 deposits on basement membrane

Type 3 RPGN- ANCA (anti-neutrophil Abs)

58

pruritis w/ high alk phos levels and high anti-mitochondrial ABs

Primary biliary cirrhosis (autoimmune destruction of intrahepatic bile ducts and cholestasis)

59

PBC relationship to Gravt v. host disease

grnaulomatous bile duct destruction
heavy lymphocyte predominant portal infiltrate

60

PBC relationship to Gravt v. host disease

grnaulomatous bile duct destruction
heavy lymphocyte predominant portal infiltrate

61

pulmonary infarcts

almost always HEMORRHAGIC d/t dual blood supply to lung

62

IV drug abuse pt dying of sepsis

endocarditis of RIGHT heart

S. Aureus> septic embolization from TV to distal pulmonary artery