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Flashcards in Test 87: All Deck (36):
1

What does human multi drug resistance ( MDR1) gene code for

P-glycoprotein: transmembrane ATP-dependent efflux pump protein that has a broad specificity for hydrophobic compounds

2

Tumor cell lines become resistant after exposure to various anticancer agents. These cells express a specific cell surface glycogprotein that functions how

- ATP-depenent transporter

3

Individuals who are successfully immunized against hep B virus develop protective

anti-HBs antibody

4

Individuals who recover from Hep B infection have what

- anti HBs
- anti- HBc

5

Human epidermal growth factor receptor 2 (HER2) is what type of receptor

tyrosine kinase receptor

6

What drug targets HER2

Trastuzumab

7

drug that is VEGF inhibitor

Bevacizumab

8

MOA for Denosumab

human monoclonal antibody against RANKL

9

What nerve causes weakness perineal musculature causing fecal and urinary incontinence, perineal pain , and sexual dysfunction?

Pudendal nerve injury

10

What is the root for the pudendal nerve

S2,3,4 keeps the penis off the floor

11

Where does the pudendal nerve reenter the pelvis

near ischial spine

12

Masculization of female infant with increased testosterone and androstenedione. Mother has virilization during pregnancy

aromatose deficiency

13

Trauma or sustained pressure to the neck of fibula can cause injury to what nerve

common peroneal nerve

14

MOA for Etanercept

TNF-alpha decoy

15

Elevated systemic blood pressure from alpha1 adrenergic agnonists does what to the heart

- increase vagal tone
- decrease heart rate
- flow AV node conduction

16

Piperacillin-tazobactam is effective against what

- gram (-) enteric rods
- bacteroides fragilis

17

Name Beta-lacatmase inhibitors

CAST
- Clavulanic Acid
- Sulbactam
- Tazobactam

18

Patient's EKG was irregularly irregular with absent P waves suggetst

atrial fibrillation

19

Bone pain and elevated alkaline phosphatase level in an elderly patient can occur with what

1. osteoblastic metastases
2. paget disease of bone

20

Potter sequence

- renal anomaly
- oligohydramnios
- compression of fetus
- pulmonar hypoplasia

21

What provides the fastest reversal of Warfarin effects

fresh frozen plasma

22

Can you give a patient with INR above 3 warfarin therapy

no

23

What is used for heparin reversal

protamine

24

What does cryoprecipitate contain

- cold-soluble proteins ( factor 8, fibrinogen, von Willebrand factor, vitronectin )

25

Where is water always impeccable in kidney

ascending limb of loop of henle

26

Most common indolent non-Hodgkin lymphoma in adults

follicular lymphoma

27

How does follicular lymphoma present

"waxing and waning" lymphadenopathy

28

Patient with persistent fluctuating lymphadenopathy, who may have had an unrelated pharyngitis ( treated with antibiotics) on initial presentation, most likely has

follicular lymphoma

29

Follicular lymphoma is derived from what type of cell

follicular B cell

30

Translocation for follicular lymphoma

14:18
over expression of bcl-2

31

psoas sign

pain is exacerbated by extension of the hip

32

KRAS is what type of cancer gene

Proto-oncogene

33

type of cancer gene APC

tumor suppressor

34

type of gene BRACA1

tumor suppressor gene

35

Type of gene RB

tumor suppressor gene

36

Type of gene TP53

tumor suppressor gene