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Flashcards in The Alcohols & Etc Deck (19):
0

Drugs used in chronic alcoholism

Naltrexone
Acamprosate
Disulfiram

1

Naltrexone

Drug used in chronic alcoholism

2

Acamprosate

Drug used in chronic alcoholism

3

Disulfiram

Drug used in chronic alcoholism

4

Naltrexone

Mechanism of action

Nonselective competitive anatgonist of opioid receptors

5

Nonselective competitive anatgonist of opioid receptors

Naltrexone

Mechanism of action

6

Acamprosate

Mechanism of action

Poorly understood NMDA receptor antagonist and GABA(A) agonist effects

7

Poorly understood NMDA receptor antagonist and GABA(A) agonist effects

Acamprosate

Mechanism of action

8

Naltrexone
Acamprosate

Clinical applications

Reduced risk of relapse in individuals with alcoholism

9

Reduced risk of relapse in individuals with alcoholism

Naltrexone
Acamprosate

Clinical applications

10

Naltrexone

Toxicity

GI effects and liver toxicity
Will precipitate a withdrawal reaction in individuals physically dependent on opioids and will prevent the analgesic effect of opioids

11

GI effects and liver toxicity
Will precipitate a withdrawal reaction in individuals physically dependent on opioids and will prevent the analgesic effect of opioids

Naltrexone

Toxicity

12

Acamprosate
Naltrexone

Clinical application

Reduced risk of relapse in individuals with alcoholism

13

Disulfiram

Mechanism of action

Inhibits aldehyde dehydrogenase, resulting in aldehyde accumulation during ethanol ingestion

14

Inhibits aldehyde dehydrogenase, resulting in aldehyde accumulation during ethanol ingestion

Disulfiram

Mechanism of action

15

Disulfiram

Clinical application

Deterrent to drinking in individuals with alcohol dependence

16

Deterrent to drinking in individuals with alcohol dependence

Disulfiram

Clinical application

17

Disulfiram

Toxicity

Little effect alone but severe and potentialy dangerous flushing, headache, nausea, vometing, and hypotension when combined with ethanol

18

Little effect alone but severe and potentialy dangerous flushing, headache, nausea, vometing, and hypotension when combined with ethanol

Disulfiram

Toxicity