Thrall's Material Flashcards
(219 cards)
1
Q
______ volume determines what percent of whole blood is made up of red blood cells via centrifugation
A
Pack Cell volume
2
Q
______ are immature red blood cells
A
Reticulocytes
*if we know how many reticulocytes are present then we know if the anemia is regenerative
3
Q
If a patient has regenerative anemia, what are the other two possible causes for the anemia?
A
Blood loss or Blood destruction
*Bone marrow is working because it is regenerative
4
Q
A cat presents with Lethargy and polydypsia. The cat has a regenerative anemia and an increased ________, therefore this is most likely a blood destructive anemia
A
Protein
*Bone marrow is working properly since the anemia is regenerative and the total protein is increased. With blood loss you normally lose protein
5
Q
The lymphopenia in this Leukogram is due to _____
A
Stress
*Most sick animals will have a lymphopenia
6
Q
Low lymphocytes are very common in _____ animals
A
Stressed
7
Q
The most common cause of Heinz Body anemia is _______ toxicosis
A
Acetametaphine
8
Q
What species is most susceptible to Heinz body formation?
A
Cats
9
Q
Only thing that causes high Albumin in a patient
A
Dehydration
10
Q
If a patient has high glucose and low phospohorous, what disease should we be thinking about?
A
Diabetes Mellitus
*phosphorus is eliminated through the kidneys
11
Q
If ALT enzyme is increased, there is usually damage to what organ?
A
Liver
*ALT is a liver enzyme
12
Q
A lethargic and polydypsic cat comes into the clinic. He is anemic and
you see heinz body formation on a blood film. The cats has a high measured Glucose and a low Phosphorous. Bilirubin, Cholesterol, and ALT are all above the reference interval. Most electrolyte counts are low. What is the most likely diagnosis in this cat?
A
Diabetic cat with ketoacidosis and secondary heinz body formation
13
Q
True/False: Electronic counting machines can distinguish banned neutrophils from segmented neutrophils
A
False
*Cannot distinguish
14
Q
Banned neutrophils are an indication of _______
A
Inflammation
15
Q
When Red blood cells are counted manually after centrifugation it is known as the Pack Cell Volume. What is it known as when the Red blood cells are calculated with an equation?
A
Hematocrit
16
Q
The _____ the RDW, the more variable the sizes of red cells that are present
A
Higher
17
Q
Patient is having periodic episodes of weakness and presents with an enlarged abdomen. What is the diagnosis?
A
Hemangiosarcoma in the abdomen
*Rupturing every couple days leading to weakness
18
Q
An increased MCV coincides with a _____ anemia
A
Regenerative
*Increased number of reticulocytes leads to an increased MCV
19
Q
If you see Acanthocytes and Schistocytes in a blood film you should be suspicious of what disease?
A
Hemangiosarcoma
20
Q
Spherocytes are diagnostic for ______
A
Immune mediated hemolytic anemia
21
Q
What is the diagnosis in this dog?
A
Immune mediated Hemolytic anemia
*Spherocytes are very diagnostic for IMHA
22
Q
Dogs with immune mediated hemolytic anemia usually have _____, which is commonly the cause of death in these animals
A
DIC
23
Q
What is the diagnosis in this puppy that is not growing adequately?
A
Hookworm leading to chronic blood loss
*Do a fecal exam to confirm diagnosis
24
Q
What is the main cause of a Microcytic anemia?
A
Iron deficiency
25
If an animal has a non regenerative anemia with a normal total protein, what is the most likely cause of anemia?
Bone marrow insufficiency
26
What is the diagnosis for this patient that is bleeing from the gums?
Bone Marrow failure
\*Bleeding due to severe thrombocytopenia
27
What is the best anticoagulant to use for a CBC because it preserves cell morphology?
EDTA
\*Lavendar/purple top tube
28
What color tube conains the anticoagulant EDTA, which preserves cell morphology, and is used for blood collection for CBC?
Lavender
29
Someone collects blood for CBC into a lavender tube, they end up deciding just to run a chemical profile and poor the blood into a red top tube. How will the chemical profile come back?
Extermely high potassium
Extermely low calcium
\* Animal would not be alive if calcium was this low
30
If you are out in the field and cannot get a blood sample to the lab for about 4-5 hours, you should use a ____ top tube because it will inhibit glucose metabolism
Gray
\*Glucose decreases 10% per hour in a red top tube
31
If blood for a CBC sits at room temperature for ____ hours or more, erythrocytes will swell resulting in increased MCV
24
32
A _____ machine is a good way to mix blood before performing any test on the blood
Tilt
\*Stirs up the blood samples to make sure the cells are not settled
33
The percentage of whole blood composed of erythrocytes that is measured after centrifugation that maximally packs RBCs
Packed cel volume
34
\_\_\_\_\_\_ will cause plasma to appear opaque and will interfere with readings. Usually associated with an animal that was not fasted prior to blood collection
Chylomicrons/ Lipemia
35
Red coloration in plasma is due to the presence of _____ that could be caused by intravascular hemolysis or improper blood collection
Hemoglobin
\*If PCV is not decreased then most likely improper technique
36
You should expect to see a difference in your serum protein versus your plasma protein due to _____ proteins that are present in plasma and not serum
Coagulation proteins
37
If total protein and PCV are both decreased, suggests \_\_\_\_\_\_
Blood loss
38
Albumin and Globulin make up \_\_\_\_\_
Total protein
\*Added together they make up the total protein
39
True/False: The most common stain used for a blood film is a combination of the Wright and Giemsa stain
True
\*Wright-Giemsa Stain
40
Best to use ____ procedure when staining a blood film in order to avoid precipitate
Dipping
41
In what area of a blood film should the differential cell count be performed?
Counting area
42
This blood film shows a lot of smaller ball shaped Red blood cells. What is this diagnostic for?
Immune mediated hemolytic anemia
\*spherocytes
43
Multiply the total nucleated cell concentration by the percentage of each leukocyte type to yield the ____ concentration of each type of nucleated cell within the blood sample
Absolute
44
Total nucleated cell count = 10,000
80% are segmented neutrophils
What is the absolute concentration of segmented neutrophils?
8,000
| (80% \* 10,000)
45
If platelets appear to be decreased, check the \_\_\_\_\_edge of the blood film for platelet clumps
Feathered
46
If MCV is 70 and you have 7 million red blood cells, what is your calculated hematocrit?
**49%**
(70x7) / 10
47
True/False: If your patient has an increased Mean Cell hemoglobin concentration then they are very sick
False
\*There is a glitch in the system- there is no such thing as an increased MCHC because red cells can only have so much hemoglobin
48
Increases in Mean cell hemoglobin Concentration are always \_\_\_\_\_\_. Erroneosly high reading due to hemolysis, lipemia or presence of Heinz bodies
Artifactual
\*Red cell can only hold so much hemoglobin
49
Usually decreases in Mean Cell hemoglobin Concentration are due to presence of reticulocytes that are still making hemoglobin and is associted with a _____ anemia
Regenerative
50
Measurement taken when leukocytes are passed through a flow cell that is intersected by a laser beam. Physical properties of the cells scatter light to different degrees which provides you the size of the cell as well as different properties
Light Scatter Measurement
| (aka Flow Cytometry)
51
Counting in which cells are suspended in an electrolyte medium that conducts electricity where deflections in current are proportional to the size of the cell
Impedence
| (Electronic cell counting)
52
Curve established for each population of cells which must be set specifically for each species
Size distrbution curve
53
True/False: Size distribution curves provide seperate curves for each population of leukocytes and the size distribution curve is unique for each species
True
54
Members of the ____ family are unique in that they have high MCHC as well as having oval shapen red blood cells
Camel
55
True/False: On a size distrubtion curve, larger red cells are further to the right, while smaller red cells fall towards the left
True
56
Describes the relative width of the Size distribution curve
Red cell distribution width (RDW)
57
What are the two main things that will increase RDW?
Population of Large blood cells
Population of Small blood cells
58
Small or microcytic red blood cells are characterisitic of \_\_\_\_\_anemia
Iron Deficiency
59
Larger or macrocytic red cells are characterisic of a \_\_\_\_\_anemia
Regenerative
\*Bigger immature cells being released
60
The _____ the RDW, the more variation in red blood cell size
Larger
61
What kind of stain will cause reticulocyte organelles to clump and contain a blue hue making it easier for diagnosis?
Brilliant Cresyl blue
62
What species typically does not have any reticulocytes in health but can release reticulocytes during a regenerative anemia?
Cows
63
What species does not have reticulocytes in health and will not release reticulocytes during regenerative anemia?
Horses
\*Never want to do a reticulocyte count on a horse
64
True/False: A dog that has a PCV of 15% should be releasing more reticulocytes than a dog that has a PCV of 25%
True
65
How long does it take after a patient becomes anemic before you see a signficant increase in reticulocytes?
24-48 hours
\*If reticulocytes are not see, the anemia may just be too acute and the bone marrow has not responded yet with production of reticulocytes
66
Band Neutrophils and Metamyelocytes in the peripheral blood is an indication for \_\_\_\_\_
Inflammation
67
This is a _____ cell that is a sign for regenerative anemia
Polychromatic
68
Rare to have _____ released into the blood, when you do see them you know inflammation is occuring
Metamyelocytes
69
True/False: We can diagnose leukemia if all the lymphocytes in circulation are either B or T cells, without a good mixture of them
True
70
Dogs with ______ often have increased numbers of Large granular lymphocytes
Erhlichiosis
71
Functions are related to immune complex reactions, such as allergic inflammation and defence against parasites
Eosinophils
72
Most common reason to see Howell Jolly bodies
Regenerative anemia
73
What three stages of neutrophil maturation are within the proliferative pool in the bone marrow?
Myeloblast
Progranulocyte
Myelocyte
74
What three stages of neutrophil maturation are within the Maturation pool of the bone marrow?
Metamyelocyte
Band Neutrophil
Segmented neutrophil
\*Do not divide
75
Unvaccinated kitten that comes into the clinic with vomiting, diarrhea and a decrease in all leukocyte counts most likely has what disease?
Panleukopenia
76
Increased concentration of immature _____ in the blood is referred to as a left shift
Neutrophils
77
True/False: If you have a left shift that is orderly, there will be more segmented than banned neutrophils and more banned neutrophils than metamyelocytes
True
78
Presence of neoplastic cells in the blood or bone marrow
Leukemia
79
The most commonly acquired change in leukocyte morphology is a neutrophil ____ change in which an accelerated rate of production of neutrophils occurs due to inflammation. Neutrophils appear abnormal with a blue cytoplasm
Toxic
\*toxic changes to neutrophils- neutrophils look different due to accelerated production and release from bone marrow
80
True/False: The rate of production of toxic neutrophils increases during times of inflammation
True
81
Relatively unimportant finding that is a result of normal aging of the neutrophil and use of corticosteroids
Neutrophil hypersegmentation
82
True/False: Neutrophil degeneration is usually due to bacteremia or sepsis
True
\*Neutrophils are falling apart due to bacterial toxins
83
Anomaly that is an inherited disorder in which neutrophils failure to segment but does not make any clinical difference. Associated with eosiniphils that also fail to segment
Pelger Huet
84
Condition in which the lysosomes fuse with neutrophils forming large pink granules within the cytoplasm of the neutrophil that is common in persian cats
Chediak Higashi Syndrome
85
Inherited disorder in which an enzyme is missing due to genetic abnormality and you begin to see lysosomes that are full of material that have not been degraded appropriately
Lysosomal Storage disorder
86
What species it is common to see a neutropenia during inflammation due to their low number of neutrophils in their bone marrow storage pool
Cows
\*very common to see neutropenia with acute inflammation in a cow
87
True/False: Dogs don't have as many neutrophils stored within their bone marrow. If the dog is not releasing neutrophils into the peripheral blood during inflammation it is not a concern up until day 5
False
\*This is true for ruminants- normal inflammatory process in ruminants.
88
During excitement, increased blood flow shifts leukocytes from the marginated pool to the circulating pool leading to \_\_\_\_\_\_
Lymphocytosis
89
If you draw blood from an excited animal what should you see?
Lymphocytosis
90
25% of cats that come into the veterinary clinic will likely have a _____ becaused they are having an excitement reaction
Lymphocytosis
91
If you see an animal with a lymphopenia, a neutrophilia as well as band neutrophils, what kind of Leukogram is this?
Stress AND inflammation
92
True/False: With stress the neutrophilia can be greater than 2 times the upper limit of the reference interval
False
\*Cannot be greater than 2 times the reference
93
During a stress response, if the neutrophilia is greater than two times the reference interval we will assume it is due to \_\_\_\_\_
Inflammation
94
If the neutrophilia is greater than two times the reference interval and we see banned neutrophils, it must be due to \_\_\_\_\_
Inflammation
95
If we see circulating lymphoblasts on a blood film the animal probably has a lymphoblastic \_\_\_\_
Leukemia
96
If there are greater than _____ lymphocytes in any species we can be comfortable that we are dealing with a Leukemia
30,000
97
When you see a dog with severe lymphocytosis, what two things could this be?
Ehrlichiosis or Lymphoid Leukemia
\*KNOW THIS
98
What is an example of irreversible bone marrow injury?
Feline Leukemia virus
\*causes complete bone marrow suppression
99
Chemotherapy drugs, Parvovirus, and panleukopenia can all lead to _____ bone marrow problems
Reversible
\*Leads to a reversible neutropenia
100
Most common cause of Lymphopenia?
Steroid Response
\*Animals are either stressed or recieveing gluococorticosteroids
101
What is the most common cause of Eosinophilia?
Parasitism
102
There is a ____ tumor that is common in dogs that has an eosinophilic chemoattractant, leading to Eosinophilia
Mast Cell tumor
103
True/False: Basophilia usually accompanies Eosinophilia
True
104
Dog 1 is an unvaccinated puppy with vomiting and diarrhea. Toxic neutrophils were seen in the blood film. What is your diagnosis?
Parvovirus
\*Toxic neutrophils and Band neutrophils mean inflammation.
105
What kind of leukogram is this for Dog 2?
Stress and Inflammation
\*Lymphopenia and Banned neutrophils
106
What type of Leukogram do we have for Dog 3?
Stress
\*Lymphopenia is present. Neutrophilia doesn't exceed twice the reference interval so not inflammation
107
What type of Leukogram is this for Dog 4?
Stress and Inflammation
\*Lymphopenia and Banned Neutrophils. Also segmented neutrophils are over twice the reference interval
108
Cat 1 has just made his first visit to the vet. What kind of Leukogram is this?
Excitment
\*Lymphocytosis
109
What is the diagnosis for Cat 2?
Leukemia
\*Has over 30,000 lymphocytes
110
Which of these 3 dogs has the worst prognosis?
Dog 2
\*His bone marrow is not keeping up with the demand for neutrophils- Very low segmented neutrophil count
111
What is the diagnosis for the Dog?
Pyometra
\*Normally dogs with pyometra will have a high neutrophil count
112
What type of Leukogram is this for a Cat?
Excitment
\*Lymphocytosis
113
Older dog that is sick with increased urination and increased drinking. What kind of Leukogram is this?
Stress and Inflammation
\*Neutrophilia that exceeds two times the reference interval and Lymphopenia
114
is the anemia in this dog regenerative?
No
\*Reticulocyte count is not increased
115
Most common cause of nonregenerative anemia in domestic animals
Anemia Chronic disease
116
What are possible reasons that this dog has a nonregenerative anemia?
Anemia of renal disease
Anemia of inflammatory disease
\*No erythropoeitin production in Kidney
117
What kind of Leukogram does Canine A have?
Inflammatory Leukogram
\*Band Neutrophils are present with a normal lymphocyte count
118
What if your diagnosis in Canine B?
Lymphoid Leukemia
\*Lymphocytes over 30,000
119
Dog with coughing and exercise intolerance. What is your diagnosis?
Heartworm disease
\*Eosinophilia and Basophilia
120
When we see and increased MCV that almost always means _____ anemia
Regenerative
121
If we see macrocytic anemia, we should be thinking \_\_\_\_\_
Regenerative anemia
122
Microcytic anemia is always due to an _____ anemia
Iron deficiency
123
What is the cause of Hypochromasia?
Iron deficiency
124
Venom from this animal will cause Red blood cells to become type III Echinocytes
Rattlesnake Envenomation
125
Red cell shape change that we can see in cats with hepatic lipidosis and sometimes in dogs with hemangiosarcoma
Acanthocyte
126
Schistocytes, which are red cell fragments, are commonly seen in what two condtions?
DIC
Vascular tumors- Hemangiosarcoma
127
If an animal present with a lot of schistocytes and is thrombocytopenic then the patient most likely has \_\_\_\_\_
DIC
\*with DIC you get a lot of microclot formation leading to
thrombocytopenia
128
In an animal that has schistocytes and decreased platelets, think\_\_\_\_\_
DIC
129
Most common disorder to see keratocyte formation
Iron deficiency anemia
130
Eccentrocytes formation is often seen in conjunction with Heinz body formation due to ingestion of _____ in dogs
Onions
131
What is the most common cause of heinz body formation in a cat?
Acetaminphen
132
What food can lead to heinz body formation in animals?
Onions
133
Animal that ingest pennies will get zinc toxicosis that can lead to ______ formation
Heniz body formation
134
What can cause Heinz body formation when ingested by horses that is very common and often fatal?
WILTED red maple leaves
135
What is the most common reason for heinz body formation in sheep?
Copper toxicosis
\*Eat forage that is high in copper and when stressed they release the copper leading to heinz body formation
136
Basophilic stippling is normal in what species?
Ruminants
137
Most common cause of basophilic stippling in small animals
Lead poisoning
\*Especially if the animal has GI and Neuro signs
138
Nucleated Red blood cells are mainly seein with \_\_\_\_anemia. If you see more than 3-4,000 per microliter then you may have a red cell leukmia
Regenerative
139
What organ has macrophages that normally remove the nucleus of red blood cells, where if this organ is non-functioning or has been removed there will be an increase in Nucleated Red blood cells and Howell jolly bodies within peripheral blood
Spleen
140
If you see Rubricytes or anything earlier in the blood then you should start worrying about a \_\_\_\_\_\_
Red Cell Leukemia
141
Protozoal parasite common in cats that is usually fatal because the parasites replicates in macrophages leading to macrophage hyperplasia that causes tissue dysfunction due to the massive number of macrophages
Cytauxzoon Felis
142
Very rare red blood cell parasite that is only see in in dogs who have had their spleen removed or the spleen in non functioning
Mycoplasma Haemocanis
\*organisms form chains
143
Red cell parasite common in cats that are ring shaped with a central area of palor inside of red cells. These parasites ride on the outside of red blood cells and antibodies directed against the parasite puncture the red cells leading to intravascular hemolysis and anemia
Mycoplasma Haemofelis
144
Red cell parasite that is economically important in cattle that leads to severe hemolytic anemia and can cause death
Anaplasma Marginale
145
Agglutination occurs when what specific antibody attaches to the Red blood cell?
IgM
146
How do you differentiate Rouleaux formation from Agglutination?
Add a drop of isotonic saline to blood
\*If rouleaux- blood cells will disperse, but if agglutination they will stay clumped together
147
What is the diagnoses in this dog with a Hematocrit of 10.8%
Bone Marrow Failure
\*All three bone marrow cell lines are decreased- Neutrophils, Red cells, and platelets
148
A dog from S.t kitts that has bone marrow failure and a high globulin concentration. What is the number one differential diagnosis?
Chronic Ehrlichiosis
149
Old dog with polyuria and polydypsia and a non regenerative anemia. What is your diagnosis?
Renal failure
\*Lack of erythropoetin and dog cannot concentrate his urine so he is drinking more water
150
If a patient has a regenerative anemia, what laboratory evaluation will help to determine if anemia is due to blood loss or blood destruction?
Total Protein
\*If animal is loosing blood acutely then we expect to see decreased protein
151
A ______ can tell us the size of the cells as well as the amount of hemoglobin inside the cells
Cytogram
152
In a Cytogram, Large cells go to the top and _____ cells go to the left
Hypochromic
153
What is the diagnosis with this histogram?
Iron deficiency anemia
\*Curve is shifted left = microcytic
154
In this histogram, the majority of Red cells are \_\_\_\_\_
Big (Macrocytic)
155
Test that can be performed when we believe an animal has Immune mediated hemolytic anemia but we are not seeing agglutination and are unsure if seeing spherocytes
Coombs Test
156
A dog with _____ will have periodic episodes of weakness
Hemangiosarcoma
157
With ____ blood loss, the protein will decrease along with the PCV
Acute
158
About 25% of dog with Hemangiosarcoma will have _____ and schiztocytes
Acanthocytes
159
This is a blood film from a dog with ______ that is bleeding into his abdomen
Hemangiosarcoma
\*Lot of acanthocytes
160
True/False: Acute blood loss causes thrombocytopenia
FALSE
\*blood loss does not cause SIGNIFICANT thrombocytopenia- platelets will only decrease slightly in actue blood loss
161
True/False: If platelet count is below 30,000 then the patient is bleeding because of thrombocytopenia
True
162
Trauma, Coagulation disorders, Bleeding tumors, and Thrombocytopenia are examples of ____ blood loss
Acute
163
GI ulcers and blood consuming parasites will lead to ____ Blood loss
Chronic
164
90% of the time a patient has chronic blood loss, the source of the blood loss is the \_\_\_\_\_
Intestine/GI tract
165
True/False: If Iron deficiency anemia has been going on for a long time then your RDW will be wide because most of the cells will be microcytic
False
\*RDW will be narrow
166
In Iron deficiency anemia, the reticuloctes will have a _____ MCV
decreased
\*Small reticulocytes due to Iron deficiency
167
Keratocyte formation is associated with what type of anemia?
Iron deficiency
168
If you have an anemic patient that is microcytic and has a low serum iron, that is enough to diangose \_\_\_\_\_
Iron deificency anemia
169
What is your diagnosis in this dog knowing that on a blood film you saw numerous Acanthocytes and Schistocytes?
Hemangiosarcoma
\*Bleeding into the abdomen
170
1 year old female pointer that has had abdominal pain the majority of its life and has been on steroids for weeks to months. If basing diagnoses on the steroid use, what is the most likely cause of pain in the abdomen and anemia?
Bleeding GI ulcers
\*Ulcers perforated leading to chronic blood loss
171
If you see a lot of neutrophils that are degenerative and falling apart you want to look around for \_\_\_\_\_
Bacteria
172
Chronic blood loss in the intestine of a very old cat is most likely due to \_\_\_\_
Tumors
173
What kind of leukogram is this?
Stress and Inflammation
174
What disease is the most common cause of blood destruction in a dog in the United States?
Immune mediated hemolytic anemia
175
IMHA, Heinz body anemia, and RBC parasites commonly cause blood \_\_\_\_\_\_
Destruction
176
True/False: Usually in Blood destruction the total protein will be normal
True
177
What breed of dog has the highest incidence of IMHA?
Cocker spaniels
178
True/False: If agglutiantion is already present on a blood film, it is indicated to perform a coombs test
False
\*Contraindicated if agglutination is already present
179
Syndrome characterized when patients with IMHA have antibodies directed against there red blood cells as well as their platelets
Evan's syndrome
180
\_\_\_\_\_ is very common in patients with IMHA, and is usually the main cause of death
DIC
181
A mismatched blood transfusion may be causing \_\_\_\_\_formation because the blood transfusion triggered IMHA
Spherocyte
182
Whenever a patients has an MCV that is way too high to be possible, there is probably \_\_\_\_\_
Agglutination
183
5 year old Cocker Spaniel comes into the clinic that is icteric and has agglutination based on the MCV. What is your diagnosis?
IMHA
\*Cocker spaniel and agglutination
184
What does this RDW curve represent?
Agglutination
185
What kind of Leukogram is this?
Stress and Inflammation
186
If and animals specific gravity is between \_\_\_\_\_, it is called isostenuric and means the animal is not able to concentrate their urine which may indicate kidney damage
1.008-1.012
187
Specific type of Immune mediated hemolytic anemia in which a neonates red cell antigens come in contact with the mother and she produces antibodies agains the neonates red cells. Foal get hemolytic anemia after ingesting the mothers colostrum
Neonatal Isoerythrolysis
188
Common blood cell parasite of cats that causes severe anemia
Mycoplasma Haemofelis
189
If a cat has Mycoplasma Haemofelis and the anemia is not regenerative, what two diseases should we test for?
Feline Leukemia Virus
Feline Immunodeficiency Virus
\*These two viruses could have predisposed the cat to M.Haemofelis infection due to immunosuppression
190
Opportunist red blood cell parasite of dogs that have been splenectomized and no longer have a spleen
Mycoplasma Haemocanis
191
Red blood parasite of cattle that typically only causes severe anemia if the animal is splenectomized
Mycoplasma Wenyonii
192
In what species is it normal to see basophilic stippling with regenerative anemia?
Ruminants
193
Most common way that horses gets Heinz body anemia
Ingestion of Wilted Red maple leaves
194
Acetaminphen toxicity in cats, not only causes heinz body formation, but can also cause \_\_\_\_\_\_
Methemoglobinemia
195
Cats that have been poisoned with Acetometaphine that have ______ will have mucous membranes that get a brownish color or a tube of blood that appears brown
Methemoglobinemia
\*Iron in the ferric state and unable to carry oxygen
196
What species stores copper in their liver and when stressed release the copper from the liver leading to copper toxicosis that can be fatal?
Sheep
197
True/False: Copper toxicosis in sheep can lead to heinz body formation
True
198
Toxicity that occurs in cattle that is common in cases where cattle have unlimited access to water leading to decreased osmolaltiy and the red cells become susceptible to lysis
Water intoxication
199
What two infectious agents commonly cause generalized bone marrow suppresion (aplastic anemia)
Ehrlichia
Feline leukemia Virus
200
Drugs that commonly cause generalized bone marrow suppression targeting rapidly replicating cells
Chemotherapy drugs
\*aka anti-neoplastic drugs
201
What infectious agent can result in either generalized bone marrow suppression or specifically red cell suppression?
Feline Leukemia Virus
202
In what type of anemia is iron stored and not released to red cell precursors so you end up getting decreased red cell production?
Anemia of Inflammatory disease
203
What can you tell based on the Reticulocyte count and MCV for this cat?
Agglutination is occuring
\*MCV and Retics are too high to make sense
204
What kind of a Leukogram is this?
Stress and Inflammation
205
15 year old Terrier with periodic episodes of weakness. What is the diagnosis?
Hemangiosarcoma
206
What kind of Leukogram is this in January?
Inflammatory and Excitment
207
If you see a high MCV in a cat with a non regenerative anemia and no agglutination then test the cat for \_\_\_\_
Feline Leukemia Virus
\*can result in big Red blood cells that are not maturing
208
What is the diagnoses in this 11 year old cat with non regenerative anemia, an increased MCV, and increased bands and segmented neutrophils. A blood film showed evidence of nucleated red blood cells back to rubriblasts in the peripheral blood
Red cell Leukemia
\*Cat is very anemic- non regenerative. Bone marrow problem- since neutrophils are still being produced at high numbers it must be specifically a red cell leukemia
209
If we see Rubriblasts and Prorubriblasts in a blood film of an animal that has normal neutrophil counts, what is the diagnosis?
Red cell Leukemia
210
In this case of non-regenerative anemia, the Leukogram shows that the bone marrow is making neutrophils and platelets. A biochemical profile shows that the dog is very azotemic and a urine analysis shows that the dog's specific gravity is 1.008. What is the most likely diagnosis?
Renal failure related anemia
\*Lack of Erythropoeitin
\*Only thing the bone marrow is not making is Red blood cells
211
In the dog, what are the two most common places to do a bone aspirate?
Trochanteric fossa
Humerus
212
In a normal animals, bone marrow is made up of \_\_\_\_% hematopoetic cells and \_\_\_\_% fat
50% for eech
213
True/False: When doing a bone marrow aspirate, you should stop after collecting about 2-3 drops of bone marrow in order to decrease your changes of blood contamination
True
214
Neutropenia, Thrombocytopenia, and Non regenerative anemia are all associated with ______ failure
Bone Marrow
215
What is the range of a normal M:E ratio
1:1 to 3:1
\*You should see 1 to 3 myeloid precursors for every erythroid precursor
216
Increased M:E ratio can be due to what 2 things?
Erythroid hypoplasia
Granulocytic Hyperplasia
217
Animal with very high M:E ratio. Neutrophil count is 83,000 with a PCV of 35%. What is the cause of the increased ratio?
Granulocytic hyperplasia
218
Dog has a decreased M:E ratio with a PCV of 20% and a neutrophil count of 12,000. What is the cause of the decreased ratio?
Regenerative Anemia
\*Increased production of red cell precursors
219
What are the three causes for a decreased M:E ratio?
Regenerative Anemia
Erythroid Leukemia
Lack of production of neutrophils
