Flashcards in Thrombocytosis Deck (7)
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1
What is thrombocytosis?
Elevated platelet count (>450,000) in peripheral blood
2
What are two causes of thrombocytosis?
Reactive thrombocytosis (overproduction of platelets) or clonal thrombocytosis (clonal expression of megakaryocytes). Reactive more common than clonal
3
What are some clinical presentations of thrombocytosis?
HA, blurry vision, dizziness, atypical CP, limp dysesthesia, erthromelalgia thrombotic and bleeding complications can occur, splenomegal, coexisting leukocytosis and erythrocytosis
4
What is the standard workup for thrombocytosis?
CBC w/ peripheral smear, serum ferritin, CRP and ESR, Philadelphia chrom, serum EPO assay, JAK2 mutation analysis, bone marrow chromosome analysis.
5
Which thrombocytosis is rarely associated with bleeding and generally doesn't require specific therapy?
Reactive thrombocytosis
6
Treatment for acute thrombocytosis?
Vasomotor sxs: ASA, bleeding: D/C NSAIDs and ASA, immediate platelet apheresis w/ a platelet lowering agent in Von Willebrands. Thrombosis: plt >800, platelet apheresis + platelet lowering agent, anticoag therapy 3-9 months
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