Thrombolytic Drugs Flashcards Preview

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Flashcards in Thrombolytic Drugs Deck (10)
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1
Q

Mechanism of action of Streptokinase

A

Binds plasminogen forming a complex that activates plasminogen to plasmin

2
Q

ADRs of Streptokinase

A

GI bleeding, Cerebral haemorrage, Produces anti-bodies

3
Q

DDIs of streptokinase

A

Bleeding with anti-coagulants

4
Q

Examples of exogenous plasminogen activators

A

Alteplase, Reteplase

5
Q

Mechanism of action of exogenous plasminogen activators

A

Activates plasminogen to plasmin

6
Q

ADRs of exogenous plasminogen activators

A

GI bleeding, Cerebral haemorrhage

7
Q

DDIs of exogenous plasminogen activators

A

Bleeding with anti-coagulants

8
Q

Risk factors for bleeding with thrombolytic drugs

A

Female, Hypertension, Cerebrovascular disease

9
Q

Contraindications for thrombolytic drug use

A

History of cerebral haemorrhage, GI trauma, or head trauma, Hypertension, Liver disease, Peptic ulcers, Bleeding disorders, or are pregnant

10
Q

Treatment for overdose of streptokinase

A

Tranexamic acid