Thrombolytic Drugs Flashcards Preview

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Flashcards in Thrombolytic Drugs Deck (10):
1

Mechanism of action of Streptokinase

Binds plasminogen forming a complex that activates plasminogen to plasmin

2

ADRs of Streptokinase

GI bleeding, Cerebral haemorrage, Produces anti-bodies

3

DDIs of streptokinase

Bleeding with anti-coagulants

4

Examples of exogenous plasminogen activators

Alteplase, Reteplase

5

Mechanism of action of exogenous plasminogen activators

Activates plasminogen to plasmin

6

ADRs of exogenous plasminogen activators

GI bleeding, Cerebral haemorrhage

7

DDIs of exogenous plasminogen activators

Bleeding with anti-coagulants

8

Risk factors for bleeding with thrombolytic drugs

Female, Hypertension, Cerebrovascular disease

9

Contraindications for thrombolytic drug use

History of cerebral haemorrhage, GI trauma, or head trauma, Hypertension, Liver disease, Peptic ulcers, Bleeding disorders, or are pregnant

10

Treatment for overdose of streptokinase

Tranexamic acid