Thrombolytics/ Fibrinolytics Flashcards Preview

Year 3 - Cardiovascular Drugs > Thrombolytics/ Fibrinolytics > Flashcards

Flashcards in Thrombolytics/ Fibrinolytics Deck (7)
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1
Q

Name some common fibrinolytics

A

Streptokinase and Altepase

2
Q

How do fibrinolytics work?

A

Plasmin breaks down the fibrin clot
Fibrinolytics catalyse the conversion of plasminogen to plasmin
As a result plasmin dissolves fibrinous clots and re-canalises occluded vessels

3
Q

What are the main uses for fibrinolytics?

A
  1. Stroke (better prognosis if used within 4.5 hours)
  2. MI - acute ST elevation MI along with antiplateles within 12 hours (PCI has superseded fibrinolytics)
  3. Massive PE - PE with haemodynamic instability
4
Q

What are the contraindications of using fibrinolytics?

A

Bleeding disorders (thrombocytopenia/haemophillia)
Peptic Ulcer
Unstable hypertension
Trauma/Sugery
Intracranial haemorrhage (needs to be excluded by CT)
Previous streptokinase treatment

5
Q

What are the interactions with fibrinolytics?

A

Risk of bleeding if used with other anticoagulants/antiplatelets
ACE inhibitors increase the risk of anaphylaxis

6
Q

What are the side effects of fibrinolytics?

A

Nausea and vomiting
Bruising at injection site
Hypotension
Bleeding, allergic reactions, cariogenic shock and cardiac arrest requires treatment to be stopped

7
Q

Are fibrinolyitcs commonly given?

A

Given with caution

Only by specialist