Thursday - Breast cancer genetics - Nikcevich Flashcards Preview

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Flashcards in Thursday - Breast cancer genetics - Nikcevich Deck (12):
1

aromatase inhibitors are only for postmenopausal women

k

if you need to use one, you can induce menopause

2

38 yo gets breast pain after giving birth
exam is unremarkable
mammogram shows vague density
next step?

MRI

3

infiltrating lobular carcinoma can be silent on the mammogram

so if it's negative, maybe do an MRI just incase

4

her2 positive

automatically high risk

5

best treatment that has ever come out for breast cancer

herceptin = trastuzumab

6

58 yo nurse. right shoulder pain
lytic lesions on humerus
biopsy shows ER+/PR+, her2 -

metastatic
got an aromatase inhibitor
metastatic is incurable
- goals of tx = symptom

7

57 yo with mass
mammo
shows grade 1 no nodes
it recurred 5 years later. now what?

PET scan shows shit everywhere. looks like chirstmas lights

went into clinical trial - follow us is a lot better

8

46. feels fine. annual mamo
shows calcification
next step?

biobsy
.6cm ductal carcinoma no invasiveness
gets a lumpectomy
got temoxofen
goal is to reduce risk of recurrence
no chemo

9

62 male. soreness behind nipple
feel something in lymph node and areola
next step?

mammo
2cm mass
ER+/PR-
stage III
tx = same as female
should be checked for BRCA becuase may help family screening
temoxofen

10

82 yo female. new density in breast on screening

2cm mass

get biopsy

non-hodgkin lymphoma. marginal zone

now what

CT showed many lymph nodes in axilla and lungs

stage 4

tx = rituximab

complete remission

basically remember, not everything is breast cancer

11

57 female w IV ovarian cancer. getting chemo

gets right breast swelling and tenderness and neurotpenic

mastitis

amoxicillin/clavulanic acid

edema stays, do another mammo. mass. biopsy.
it's metastatic to breast from ovary

12

gail model

measures age, reproductive risk. family hx and biopsy hx

not applicable to
women with prior cancer
under 35
hx of chest radiation
BRCA mutations
men