Thyroid Gland & Disease Flashcards Preview

Clinical Biochemistry > Thyroid Gland & Disease > Flashcards

Flashcards in Thyroid Gland & Disease Deck (45):
1

How many parathyroids?

4

2

What do parathyroids do?

Regulate the body's metabolism

3

What is the Thyroid?

Plays an important role in metabolism, situated at the front of the neck

4

The tissue connecting the two lobes?

Isthmus

5

How many thyroid hormones are there and what are they called?

1-thyroxine (T4)
2-triiodothyronine (T3)
3-reverse triiodothyronine

6

3 primary sections of a thyroid (histology)

Follicles
Follicular cells
Para follicular cells

7

What is the function of the follicles, follicular cells and the para follicular cells?

1-follicular, absorb iodine
2-F.C, secrete t3 and t4
3-para follicular, secrete calcitonin

8

Function of iodide

Aid to generate t3 and t4

9

Function of thyroid hormones

Growth
Development
Transporters (amino acid)
Stimulate gene expression

10

Thyroid transport in the blood

Thyroxin binding globulin (TBG) carries most t3 and t4.
Unbound (free) t3 and t4 very important, however very low

11

Major route of excretion?

Hormone degradation by deiodination and metabolism in tissues

12

Hyperthyroidism?

Over active thyroid

13

Hypothyroidism

Underactive thyroid

14

Euthyroid

Normal functioning thyroid

15

Another name for hypothyroidism?

Myxoedema

16

Hashimotos disease

Low t4
Antibodies destroys thyroid gland (primary)
Hypothyroidism

17

Signs of hypothyroidism

Weight gain
Slow speech
Dry skin
Bradycardia

18

TFT?

Thyroid function test:
Helps diagnosis of thyroid disease

19

Treatment for hashimoto disease?

Thyroid replacement therapy

20

Another name for hyperthyroidism?

Thyrotoxicosis

21

Cause of hyperthyroidism?

Graves' disease (most common)

22

Signs of hyperthyroidism

Sweating
Weight loss
Tremor

23

Graves' disease?

Autoimmune
Mostly females
Control of t4 synthesis decrease

24

Toxic multi modular goitre

Iodine deficiency
Induction to thyroid cell hyperplasia

25

Treatment?

Surgery
Thyroid hormone replacement
Beta blocker
Iodine therapy

26

2 hypothalamus pituitary thyroid axis

TSH
TRH

27

If patients thyroid hormone is too high...

TSH will be suppressed

28

If patients thyroid hormone is too low

TSH levels will be too low

29

Thyroid function tests

...aids diagnosis

30

2 hypothalamus pituitary thyroid axis

TSH
TRH

31

If patients thyroid hormone is too high...

TSH will be suppressed

32

If patients thyroid hormone is too low

TSH levels will be too low

33

Thyroid function tests

...aids diagnosis

34

2 hypothalamus pituitary thyroid axis

TSH
TRH

35

If patients thyroid hormone is too high...

TSH will be suppressed

36

If patients thyroid hormone is too low

TSH levels will be too low

37

Thyroid function tests

...aids diagnosis

38

2 hypothalamus pituitary thyroid axis

TSH
TRH

39

If patients thyroid hormone is too high...

TSH will be suppressed

40

If patients thyroid hormone is too low

TSH levels will be too low

41

Thyroid function tests

...aids diagnosis

42

2 hypothalamus pituitary thyroid axis

TSH
TRH

43

If patients thyroid hormone is too high...

TSH will be suppressed

44

If patients thyroid hormone is too low

TSH levels will be too low

45

Thyroid function tests

...aids diagnosis