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Cell Metabolism > Tooth Development > Flashcards

Tooth Development Flashcards

1
Q

What represents the beginning of odontogenesis?

A

The appearance of dental lamina arising from the oral epithelium

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2
Q

Adontia, stage?

A

Congenital absence of ALL teeth
Associated with Ectodermal Dysplasia
During initiation

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3
Q

Partial Adontia, Stage?

A

Hypodontia (1-5 teeth missing)
Oligodontia (>6 teeth missing)
Developmental disturbance with dental lamina formation
No tooth germs
Max latereal incisors are the most common to be missing
During initiation

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4
Q

Hyperdontia (Polydontia), stage?

A 
Extra teeth
permamnent dentition
Mesiodens, common example
Extra tooth germ is formed
During Initiation
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5
Q

Primary Epithelial band formation

A 
Thickened epithelium (ectoderm) in place of future jaws
Rapid cell division gives rise to 2 subdivisions dental lamina and vestibular lamina
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6
Q

Bud Stage

A

Oral epithelium invaginates into the ectomesenchyme which will condensate

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7
Q

What does dental lamina rise from?

A

Ectoderm lining of stomadeum –> oral epithelium –> dental lamina

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8
Q

What influences the ectomesenchyme?

A

Neural crest cells

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9
Q

Lateral lamina

A

Tethers the bud of dental lamina

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10
Q

Cap stage

A

Epithelial outgrowth of enamel orga forms cap over ectomesenchyme
Bud–> Enamel organ
Ectomesenchyme–>Dental Papilla
Dental follicle surrounds the enamel organ and dental papilla
Inner enamel epithelium become ameloblasts

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11
Q

Degeneration of the vestibular lamina gives rise to what structures
(Cap stage)

A 
Epithelial lining for 
Oral vestibule
Alveolar mucosa
Parts of gingival mucosa
Inner lip mucosa
Mucosal space btw the cheeks or lips
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12
Q

Dens in dente, what stage?

A

Tooth within a tooth
Enamel organ expands more than it should and invaginates into the dental papilla
During cap stage

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13
Q

Fusion, stage?

A

Union of 2 teeth by dentin and enamel
Fewer number of teeth
Extra wide crown with 1 pulp cavity
During Cap stage

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14
Q

Gemination, stage?

A

1 tooth attempting to divide, abnormally wide crown, incomplete
Correct number of teeth
During Cap stage

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15
Q

Bell Stage General

A

Deepening of the undersurface
Morphodifferentiation
Histodifferentiation
Dental lamina disintegrates

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16
Q

Morphodifferentiation

A

Occurs during Bell stage

Enamel organ takes on the shape of an incisor, canine, or molar

17
Q

Histodifferentiation

A

During bell stage

Ameloblasts (enamel) and odontoblasts (dentin) acquire their phenotype

18
Q

Tooth germ consists of

A

Enamle organ, dental lamina, dental papilla

19
Q

Bell Stage In depth

A

Dental lamina disintegrates
Tooth continues to develop separate from the oral epithelium
Crown pattern established
Stellate reticulum thin over cusp tip
Stratum intermedium assists ameloblasts and nourishes them

20
Q

Early Bell Stage

A

Histodifferentiated enamel organ (cervical loop region) is supported by basal lamina around periphery

21
Q

Development of Succedaneous Teeth

A

Proceed through all the same stages of odontogenesis as primary teeth do

22
Q

Permanent Molar development

A

Posteriormost extent of dental lamina does not disintegrate, elongates in a posterior direction giving rise to 12 buds –> permanent molars

23
Q

Incisors, canines, and premolar development

A

Form due to further proliferative activity within the dental lamina
On lingual aspect of deciduous tooth germ

24
Q

Dental Papilla cells

A

Peripheral cells of papilla face Inner enamel epithelium and differentiate into odontoblasts which secrete dentin
Inner cells of dental papilla form pulp

25
Q

Dental Follicle Cells

A

Inner cells closest to the enamle organ become cementocytes and form cementum
Outer cells form PDL and contribute to alveolar bone formation

26
Q

Which 2 cells help in formation of enamel?

A

Stratum intermedium and Inner enamel epithelium

27
Q

Cervical Loop region/Zone of Flexion of the Enamel Organ

A

Hertwigs Epithelial Rooth Sheath (HERS) joining of IEE and OEE
Initiates root formation
Gives rise to epithelial component of root after crown is formed

28
Q

Cervical Loop cont.

A 
Rapid cell division within cervical loop
Enamel organ elongates
Depth of the concavity increases and enamel organ resembles bell
Crown joins the root
Enamel joins the cementum
29
Q

Crown pattern Development

A

Pattern and number of cusps is establishedby complete folding of the IEE (morphodifferentiation)

30
Q

What causes folding of IEE?

A

Intrinsic growth caused by differential rates of mitotic division within the IEE
Stellate reticulum over cusp tips is reduced

31
Q

Epithelial Pearls or Rests of Serres

A

Fragmentation of dental lamina results in discrete clusters of epithelial cells surrounded by connective tissue and normally degenerate
Some are phagocytosed
If they persist they are deemed Epi Pearls/ Rests of Serres

32
Q

What could Epithelial Pearls form?

A

Eruption cysts- cells form over developing tooth and delay eruption
Odontomes, or activated to form supernumerary teeth

33
Q

Cusp Development

A

Growth center- point at which IEE cell differentiation first occurs –> site of future cusp development
A 2nd xone of differentiation within IEE leads to second cusp and so on

34
Q

Enamel Knot (Ahrens Knot)

A

Embryonic signaling center- provides positional info for tooth morphogenesis
Ectomesenchymal cells of papilla induce cells of knot to express signaling molecules
Know cells control folding of IEE (cuspal morpho)
Incisors have 1 know Molars have multiple
Knots undergo apoptosis

35
Q

Enamel Cord

A

Associated with the placement of the 1st cusp

Also called enamel septum

36
Q

Microdontia, stage?

A

Small teeth
Max incisors and 3rd molars often affected
Peg lateral
During Bell stage

37
Q

Macrodontia, stage?

A

Large teeth

Uncommon, associated with Hemifacial Hypertrophy

38
Q

Amelogenesis Imperfecta, stage?

A

Hereditary, enamel formation disorder

39
Q

Dentinogenesis Imperfecta

A

Hereditary affects dentin

Clear yellow grey teeth

Cell Metabolism (16 decks)

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