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Flashcards in Topic 2 Deck (19):
1

What are the considerations of absorption

best route of administration; will food or other factors affect absorption

2

What are the considerations of distribution

will enough of the drug be freely circulating

3

What are the considerations of metabolism

how much will be lost to metabolism; properties of metabolites; changes and variations in enzyme activity

4

What are the considerations of excretion

how does the body remove the drug

5

Do the processes (ADME) always happen in that order

although the distribution of drugs usually follows absorption, the processes do not always occur in sequential order.

6

Absorption

when drugs travel from the site of administration into the bloodstream or circulation.

7

Drugs have to be … to work

absorbed

8

Which administration methods do not involve absorption and why

intravenous and intra-arterial as these are both directly into the bloodstream

9

What is absorption affected by

1) where the drug was administered, 2) the chemical properties of the drug

10

When does a drug face its biggest hurdles

during the absorption process

11

What happens when a drug is taken orally

it passes through the digestive tract and is absorbed from the stomach and intestines.

12

Examples of how can medicines be modified to improve absorption

enteric coating, rapid dissolving

13

Where are oral drugs absorbed

through the GI epithelium

14

What types of drugs can be for transdermal administration

systematically acting drugs; and locally acting drugs

15

Subcutaneous must move from where into bloodstream

subcutaneous fat

16

All drugs that have to be absorbed must cross

the plasma membrane to enter the bloodstream

17

Rate of absorption

how quickly

18

Extent of absorption

how much

19

What are the ways in which drugs can be inactivated before absorbed (3)

1) some drugs, such as insulin or glyceryl trinitrate may be susceptible to digestive or liver enzymes and be inactivated before being absorbed. 2) Others may interact with nutrients in the digestive tract and this may impede their absorption. 3) Some drugs may be unstable in the acidic environment in the stomach.