Transplant 2

Question 1

Pathological finding of acute cellular rejection (of lung transplant)

Answer 1

Lymphocytic aggregates around arterioles or bronchioles

Question 2

When does acute cellular rejection usually occur after lung transplant?

Answer 2

First 6-12 months

Question 3

Tx for acute cellular rejection

Answer 3

Short course of high-dose steroids

Question 4

Possible treatments for humoral rejection of lung allograft

Answer 4

Plasmapheresis, IVIg, rituximab (deplete antibodies)

Question 5

Target of rituximab

Answer 5

CD20 (on B-cells)

Question 6

Most common viral infection in lung transplant recipients

Answer 6

CMV

Question 7

Define chronic lung allograft dysfunction (CLAD)

Answer 7

Persistent decline in FEV1 of 20% from post-transplant baseline

Question 8

2 main types of CLAD

Answer 8

BOS and RAS (restrictive allograft syndrome)

Question 9

most common malignancy in transplant pts after from non-melanoma skin cancers

Answer 9

post-transplant lymphoproliferative disorder (PTLD)

Question 10

Tx for post-transplant lymphoproliferative disorder (PTLD)

Answer 10

Rituximab & reduced immunosuppression

Question 11

Rituximab is a _____ monoclonal Ab.

Answer 11

CD20

Question 12

Always refer CF pts for transplant if FEV1

Answer 12

30%

Question 13

3 criteria for lung transplant in CF pts (if FEV1 <40%)

Answer 13

> 2 exacerbations/yr (or 1 requiring NIV);
massive hemoptysis;
pneumothorax