Flashcards in Treatment and Control of Bacterial and Fungal Infections Deck (26):
Compounds that disinfect living tissue
Compounds that disinfect non-living surfaces
What is the single most important infection control measure?
Validated process used to render a product free of all forms of microorganisms, including all bacterial endospores
Elimination of most if not all pathogenic microorganisms EXCLUDING spores
Reduction of pathogenic mocroorganisms to a level where items are "safe to handle" without protective attire
Drugs that destroy microbes, prevent their multiplication or growth, or prevent their pathogenic effect
Substance produced by a microorganism that inhibits or kills other microorganisms
Any substance of synthetic, semisynthetic, or synthetic origin that inhibits the growth of microorganisms but causes little or no damage to the host
All _____ are ______, but not all _____ are _____
Antibiotic, antimicrobial, antimicrobial, antibiotc
How are antimicrobials classified?
Mode of action
Antibacterials active against both Gram-positive and Gram-negative organisms
Antibacterials with limited activity and are primarily only useful against particular species of microorganisms
Type of antimicrobial activity that kills bacteria
Type of antimicrobial activity that inhibits bacterial growth
What are the two types of Antimicrobial Susceptibility Testing?
Disk diffusion test and broth/agar dilution test
Minimum amount of drug required to inhibit bacterial growth
Minimum inhibitory concentration (MIC)
Drug concentration above which an organism is considered resistant and at or below this value organism is susceptible to that drug
Susceptibility break point
What are the three susceptible break point values?
Susceptible, intermediate, resistant
Must use a bacterial isolate in pure culture for this AST
Disk diffusion test
Which AST uses both diffusion and dilution
Gradient diffusion test, E-test
Susceptibility results interpret...
Likelihood of therapeutic success/failure, uncertain therapeutic outcome
Fate of the drug in the body (absorption, transformation, distribution, elimination)
Effect of the drug on the body, mechanism of action and efficacy
Preexisting genomic property contributes to _____ resistance