Treatment of Angina Flashcards Preview

CV PHARM...Intro to CV Pharmacology > Treatment of Angina > Flashcards

Flashcards in Treatment of Angina Deck (9)
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1

Nitrate MOA

Endothelial NO activates GC-->increases cGMP-->de-PP of MLCK-->relaxation of VSM

Venodilation--> decreases preload and afterload-->decreases myocardial O2 demand

2

Nitrate indications

Acute angina (nitroglycerin)
pulmonary edema

3

Nitrate side effects

reflex tachycardia
orthostatic hypotension
headache
tachyphylaxis

4

CCBs MOA

inhibit voltage-gated L-type Ca channels and decreases Ca influx in cardiac and VSM; decreases muscle contractility

arteriolar vasodilation--> decreases afterload--> decreases myocardial O2 demand-->decreases AV node conduction

5

CCBs indications

angina
HTN
SVT (except nifedipine)

6

CCBs side effects

cardiac depression
peripheral edema
constipation

7

BBs MOA

beta-adrenergic antagonism

decreased contractility, dec. HR, dec BP (mild), dec myocardial O2 demand, dec AV node conduction velocity

8

BB indications

Angina
HTN
arrhythmia

9

BB side-effects

impotence
depression
bradycardia