Tumor Markers Flashcards
Match cancer marker to organ(s) affected
0
Q
CEA
A
Colon and other GI
1
Q
PSA
A
Prostate
2
Q
CA125
A
Ovaries
3
Q
HER2/neu
A
Breast
4
Q
CD20
A
B-cell lymphoma
5
Q
C-kit
A
GI stromal
6
Q
EGFR
A
Lung and colon cancer
7
Q
Cytokeratins
A
Carcinomas
8
Q
Thyroglobulin
A
Thyroid
9
Q
Lewis a antigen (CA 19-9)
A
Pancreas and GI
10
Q
Estrogen and progesterone
A
Breast
11
Q
Chromogranins
A
Neuroendocrine
12
Q
Synaptophysin
A
Neuroendocrine
13
Q
Leu-7 (CD57)
A
Neuroendocrine
14
Q
CK20
A
Colon
15
Q
HMB-45 and S-100
A
Melanoma
16
Q
Vimentin
A
Soft tissue sarcoma
17
Q
Desmin
A
Smooth or striated muscle
18
Q
Muscle-specific actin
A
Muscle
19
Q
Neurofilament proteins
A
Neurons (ex. neuroblastoma and ganglioneuroma)
20
Q
GFAP, Glial Fibrillary Acidic Protein
A
Astrocytes, other glial cells
21
Q
LCA (CD45)
A
Leukocyte common antigen - malignant lymphoma
22
Q
Factor VIII related antigen
A
Vascular tumors (ex. hemangioma, hemangiosarcoma)
23
Q
AFP
A
Liver or non-seminomatous germ cell (yolk sac) tumors
24
PCNA
Proliferating cell nuclear antigen - cell proliferation
25
PLAP, placental alkaline phosphatase
Seminoma or embryonal carcinoma (testis or ovary)
26
hCG
Trophoblastic tumors, ex. choriocarcinoma (placenta)
27
Calcitonin
Thyroid
28
Bcl-1 and cycling D1
Mantle cell lymphoma
29
Pigmented metastases
Malignant melanoma
31
CD4
T cells
32
Ki-67
cell proliferation
