Tumor Markers (Part 3) Flashcards Preview

Chemistry Module 4 > Tumor Markers (Part 3) > Flashcards

Flashcards in Tumor Markers (Part 3) Deck (14):
1

What is useful in the detection of pancreatic and colorectal cancer

Blood Group Antigen: CA 19-9

2

used as a marker for multiple myeloma for over 100 years

Protein Marker: Immunoglobulins

3

Histological marker for melanoma and melanoma metastases

Protein Marker: S-100

4

Used to diagnose differentiated thyroid cancer

Protein Marker: Thyroglobulin and antibodies

5

Used as indicators for therapy in breast cancer

Estrogen and Progesterone Receptors

6

Neuroblastoma and AML and 95% of pancreatic cancers

Genetic oncogenes: ras

7

If activated, there is an association with B- and T-cell lymphoma

Genetic oncogenes: c-myc

8

Amplification is found in breast tumors and used for prognosis

Genetic oncogenes: Her-2/neu

9

Expressed in lymphomas, myeloma, and chronic leukemias

Genetic oncogenes: bcl-2

10

Useful in the diagnosis and in the directing of treatment in CML

Genetic oncogenes: BCR-ABL

11

Loss of banding on this gene leads to a rare pediactric tumor called retinoblastoma

Tumor-Suppressor Genes: Retinoblastoma gene

12

Deletions in this gene may bead to colon carcinoma

Tumor-Suppressor Genes: p53 gene

13

Loss leads to colorectal cancer with or without many polyps

Tumor-Suppressor Genes: APC

14

Reasonably certain prediction that the woman will develop breat (85% of patients) or ovarian cancer (45%) by the age of 85

Tumor-Suppressor Genes: BRCA1 and BRCA2