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Flashcards in Tumor rejection Deck (9)
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1

Mechanisms for hyper acute rejection

preformed antibodies to graft (e.g ABO)

2

Morphology of hyperacute rejection

cyanosis and gross molting
aterial fibrinoid necrosis
capillary thrombotic oculsion

3

Time course of acute graft rejection

less than 6 months

4

Mechanism of acute rejection

CD4 t cells against the donor antigens
humoral and cellular immune response

5

morphology of acute rejection

humoral: c4 deposition (classical and mbl), pmns, necrotizing vasculitis
cellular: lymphocytes n the interstitium and endothelium

6

timecourse of chronic rejection

months to yrs

7

mechanisms of chronic rejection

chronic, low grade immune response (usually cd8) refractory to immunosuppressants

8

morphology of chronic immune response

vascular wall thickening and luminal narrowing
interstitial fibrosis and parenchymal atrophy

9

Onset for hyperacute rejection

mins to hrs