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Flashcards in Tumor Suppressor Genes Deck (16)
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1

Retinoblastoma?

Rb

2

Osteosarcoma?

Rb

3

Li-Fraumeni?

p53

4

Breast and ovarian?

BRCA1 and 2

5

Melanoma?

p16, BRAF

6

Colorectal cancer (assoc with FAP)?

APC

7

Wilm's tumor (nephroblastoma)?

WT1

8

Pancreatic cancer?

DPC4 (Deleted in Pancreatic Cancer)

9

Colon cancer?

DCC (Deleted in Colon Cancer)

10

Rb?

Inhibits E2F; blocks G1-->S phase

11

p53?

Txc factor for p21, blocks G1-->S phase

12

BRCA1 and 2?

DNA repair protein

13

NF1?

RAS GTPase activating protein (RAS-GAP)

14

NF2?

Merlin (schwannomin) protein

15

What Chr is Rb found?

Chr 13

16

What Chr is p53 found?

Chr 17