Flashcards in Tumor Suppressors and Oncogenes Deck (29):
What is bcr-abl?
Abl: Signal transducer/tyrosine kinase; Translocated genetic material, t(9;22) -> increased tyrosine kinase activity
What is ras?
Proto-oncogene, Signal transducer/GTPase, uses G-protein/MAP-kinase pathways that lead to increased sensitivity of cells to mitogenic stimuli, associated with colon, lung, and panc cancer
What is Erb-B2?
Protooncogene, growth factor receptor > increased tyrosine kinase activity related to EGFRAssociated with breast and ovarian cancer.
What is p53?
Tumor suppressor, regulates cell proliferation during G1 phase. Detects genomic abnormalities. Halts cell cycle if abnormal. If cannot repair, causes cell to apoptose.
What is N-myc?
Proto-oncogene, transcription factor, amplified in neuroblastoma.
What is neurofibromin?
Tumor suppressor protein encoded by NF-1 on Chromosome 17. Suppresses Ras (a poweful activator of cell growth and proliferation).
What is Bcl-2?
Apoptosis inhibitor(implicated in follicular lymphomas t(14;18))
What are c-Jun and c-Fos?
Proto-oncogenes, nuclear transcription factors that directly bind DNA via a leucine zipper motif.
What is c-myc?
Proto-oncogene, transcription factor, associated with t(8;14) Burkitt lymphoma
What is L-myc?
Proto-oncogene, transcription factor, associated with lung carcinoma (small cell)
What is Cyclin D1?
Proto-oncogene, enables cell cycle progression, associated with Mantle Cell Lymphoma [t(11;14)]
What is CDK4?
Proto-oncogene, enables cell cycles progression (amplification mutation), associated with melanomas
What is RET?
Proto-oncogene, neural growth factor receptor (point mutation), associated with MEN 2A and 2B, and medullary thyroid carcinoma
What is KIT?
Proto-oncogene, stem cell growth factor receptor (point mutation), associated with GI and stromal tumors
What is ERBB2?
Proto-oncogene, epidermal growth factor receptor, associated with breast carcinomas
What is PDGFB?
Proto-oncogene, platelet-derived growth factor, associated with astrocytomas
What is BRAF?
Proto-oncogene, serine/threonine kinase, melanomas
What is APC?
Tumor suppressor, Colorectal cancer (first step)
What is BRCA?
Tumor suppressor, DNA repair protein, breast and ovarian ca
What is CPD4/SMAD4?
Tumor suppressor, "Deleted in Panc Cancer" Protein (DPC), pancreatic cancer
What is DCC?
Tumor suppressor, "Deleted in Colon Cancer" protein, colon cancer
What is MEN1?
Tumor suppressor, MEN1 (autosomal dominant) cancers
What is NF2?
Tumor suppressor, Ch 22 Merlin, causes NF2 cancers
What is p16?
Tumor suppressor, CDK2 inhibitors (stops cell cycle progression), melanoma
What is PTEN?
Tumor suppressor, associated with breast, prostate, and endometrial cancers
What is Rb?
Tumor suppressor, E2F inhibitor (blocks G1->S), retinblastoma/osteosarcoma
What is TSC1/2?
Tumor suppressor, Hamartin/Tuberin proteins respectively, Tuberous sclerosis tumors
What is VHL?
Tumor suppressor, inhibits HIF1alpha, Ch3, pheochromocytomas/retinal hemangioblastomas/clear cell RCC/neurendocrine tumors/et al.