Tumor Suppressors and Oncogenes Flashcards Preview

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Flashcards in Tumor Suppressors and Oncogenes Deck (29):
1

What is bcr-abl?

Abl: Signal transducer/tyrosine kinase; Translocated genetic material, t(9;22) -> increased tyrosine kinase activity

2

What is ras?

Proto-oncogene, Signal transducer/GTPase, uses G-protein/MAP-kinase pathways that lead to increased sensitivity of cells to mitogenic stimuli, associated with colon, lung, and panc cancer

3

What is Erb-B2?

Protooncogene, growth factor receptor > increased tyrosine kinase activity related to EGFRAssociated with breast and ovarian cancer.

4

What is p53?

Tumor suppressor, regulates cell proliferation during G1 phase. Detects genomic abnormalities. Halts cell cycle if abnormal. If cannot repair, causes cell to apoptose.

5

What is N-myc?

Proto-oncogene, transcription factor, amplified in neuroblastoma.

6

What is neurofibromin?

Tumor suppressor protein encoded by NF-1 on Chromosome 17. Suppresses Ras (a poweful activator of cell growth and proliferation).

7

What is Bcl-2?

Apoptosis inhibitor(implicated in follicular lymphomas t(14;18))

8

What are c-Jun and c-Fos?

Proto-oncogenes, nuclear transcription factors that directly bind DNA via a leucine zipper motif.

9

What is c-myc?

Proto-oncogene, transcription factor, associated with t(8;14) Burkitt lymphoma

10

What is L-myc?

Proto-oncogene, transcription factor, associated with lung carcinoma (small cell)

11

What is Cyclin D1?

Proto-oncogene, enables cell cycle progression, associated with Mantle Cell Lymphoma [t(11;14)]

12

What is CDK4?

Proto-oncogene, enables cell cycles progression (amplification mutation), associated with melanomas

13

What is RET?

Proto-oncogene, neural growth factor receptor (point mutation), associated with MEN 2A and 2B, and medullary thyroid carcinoma

14

What is KIT?

Proto-oncogene, stem cell growth factor receptor (point mutation), associated with GI and stromal tumors

15

What is ERBB2?

Proto-oncogene, epidermal growth factor receptor, associated with breast carcinomas

16

What is PDGFB?

Proto-oncogene, platelet-derived growth factor, associated with astrocytomas

17

What is BRAF?

Proto-oncogene, serine/threonine kinase, melanomas

18

What is APC?

Tumor suppressor, Colorectal cancer (first step)

19

What is BRCA?

Tumor suppressor, DNA repair protein, breast and ovarian ca

20

What is CPD4/SMAD4?

Tumor suppressor, "Deleted in Panc Cancer" Protein (DPC), pancreatic cancer

21

What is DCC?

Tumor suppressor, "Deleted in Colon Cancer" protein, colon cancer

22

What is MEN1?

Tumor suppressor, MEN1 (autosomal dominant) cancers

23

What is NF2?

Tumor suppressor, Ch 22 Merlin, causes NF2 cancers

24

What is p16?

Tumor suppressor, CDK2 inhibitors (stops cell cycle progression), melanoma

25

What is PTEN?

Tumor suppressor, associated with breast, prostate, and endometrial cancers

26

What is Rb?

Tumor suppressor, E2F inhibitor (blocks G1->S), retinblastoma/osteosarcoma

27

What is TSC1/2?

Tumor suppressor, Hamartin/Tuberin proteins respectively, Tuberous sclerosis tumors

28

What is VHL?

Tumor suppressor, inhibits HIF1alpha, Ch3, pheochromocytomas/retinal hemangioblastomas/clear cell RCC/neurendocrine tumors/et al.

29

What is WT1/2?

Tumor suppressor, Wilms tumor - nephroblastoma