Tumors and Tumor-like Conditions of Fibrous Origin (Soft Tissue Tumors) Flashcards Preview

Unit 6: Path - Bones and Joints > Tumors and Tumor-like Conditions of Fibrous Origin (Soft Tissue Tumors) > Flashcards

Flashcards in Tumors and Tumor-like Conditions of Fibrous Origin (Soft Tissue Tumors) Deck (12):
1

What does Nodular Fasciitis mimic?


Benign lesion that may mimic a sarcoma

2


What about nodular fasciitis causes patients to seek medical attention?


Although it is benign, it is rapidly growing

3


What is a locally aggressive proliferation of fibroblasts?


Fibromatosis

4


Another name for fibromatosis?


Desmoid tumor

5


What mutation is found in most cases of fibromatosis?


Inactivating mutation in the APC gene

6


Describe the molecular pathogenesis of fibromatosis


APC typically enhances the degradation of Beta-catenin. With APC mutated, Beta-catenin remains stable allowing for tumor growth

7


What is the most common form of fibromatosis?


Palmar fibromatosis (Dupuytren contracture)

8


What is another name for penile fibromatosis?


Peyronie disease

9


What is a malignant tumor of fibroblasts?


Fibrosarcoma

10


What is the name of the densely interlacing bundles and fascicles found in a fibrosarcoma?


Herringbone pattern

11


What is the most common soft tissue sarcoma?


Undifferentiated Pleomorphic Sarcoma

12


What is another name of the undifferentiated pleomorphic sarcoma?


Malignant fibrous histiocytoma