What does Nodular Fasciitis mimic?
Benign lesion that may mimic a sarcoma
What about nodular fasciitis causes patients to seek medical attention?
Although it is benign, it is rapidly growing
What is a locally aggressive proliferation of fibroblasts?
Another name for fibromatosis?
What mutation is found in most cases of fibromatosis?
Inactivating mutation in the APC gene
Describe the molecular pathogenesis of fibromatosis
APC typically enhances the degradation of Beta-catenin. With APC mutated, Beta-catenin remains stable allowing for tumor growth
What is the most common form of fibromatosis?
Palmar fibromatosis (Dupuytren contracture)
What is another name for penile fibromatosis?
What is a malignant tumor of fibroblasts?
What is the name of the densely interlacing bundles and fascicles found in a fibrosarcoma?
What is the most common soft tissue sarcoma?
Undifferentiated Pleomorphic Sarcoma
What is another name of the undifferentiated pleomorphic sarcoma?
Malignant fibrous histiocytoma