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Flashcards in Tutorial week 11 Deck (115)
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1

an ________________ involves using a laboratory animal in a specific testing situation to determine the behavioural changes induced by a drug, a genetic manipulation or some manipulation of the brain.

animal model

2

the utility of a behaviour test can be considered in terms of its _______________

predictive validity

3

a good behavioural test is one that can reliably predict useful outcomes in __________

humans

4

___________ issues are important; the less invasive and harmful the test for the animal, the better it is

ethical

5

_____________________ currently spend $30 billion per year on R&D

Pharmaceutical companies

6

the biggest area of research is _________________

CNS medications

7

there are currently 10,000 knockout mice and many thousands more types with random mutations.

functional genomics

8

animal models are very widely used in _____________ research

behavioural neuroscience

9

assessing acute and long-term effects of drugs, particularly drug abuse, on behaviour is important in __________________

psychopharmacology

10

how did the overall behaviour of rat given cannabis (THC) differ from the rat given placebo

THC - not moving; anxious
placebo - energetic

11

does the hot plate cause tissue damage to the rat? why?

No, the hot plate will only damage the tissue of the rats if they were to be placed in the hot plate for more than 86 seconds. temperature was set up to not exceed 86 seconds.

12

name some drugs that produce catalepsy in rats

THC, morphine, sedatives, benzodiazepine, and anti-psychotic drugs

13

what does an anxiolytic drug typically do to behaviour on the elevated plus maze

rats with placebo - they go to closed space
rats with THC - anxiety depression; they go to opened space

14

why must testing high doses of alcohol or benzodiazephine on the plus maze be problematic

it has sedative effects
feeling less anxious

15

what is the brand name for chlorodiazepoxide

librium

16

describe the effects of high dose of amphetamine

stereotype behaviour

17

what kind of drug can be given to block stereotype induced by amphetamine

dopamine antagonist

18

what was the difference between pure THC and THC cannabidol on the reporter?

Pure THC- found in cannabis; psychoactive; paranoid; depressed
THC and cannabidol - she couldn't stop laughing; euphoric

19

what might be the effect of smoking marijuana that's been breed to contain high THC levels?

family history of risk factors - increase in THC will lead to depression
individual variability/differences

20

compare the reporter's response to THC to that of the rat earlier. what does this tell us about the utility of using a rat model for exploring the neurobiology of drugs on people?

confirmation that these drugs affects rats.
emotional effects that are applicable to humans.

21

___________ allows analgesuc properties of drugs to be assessed

the hot plate test

22

rats are placed on a hot plate at _____

50 degrees Celsius

23

the hot plate test is important when investigating new _____________

analgesic (pain relieving) grugs

24

____________ allows assessment of catalepsy

the bar test

25

a drug that increase response latency in this test has ___________ properties and may well impair _________ in human

cataleptogenic; motor function

26

____________________ is a common test for anxiety. it's not thought to examine a rat's fear of height, but rather it exploits the rat's natural fear of open spaces, and its preference for maintaining vibrissal contact with its environment.

elevated plus maze

27

normally, a rat in EPM will spend about ______ of its time in the enclosed arms

80%

28

___________________ is repetitive, stereotyped, and seemingly purposely behaviour that is induced by high dose repeated doses of stimulant drugs.

stereotype

29

stereotype is associated with a hyperdopaminergic state in the dorsal (where/spatial processing) and ventral (what/obj. processing) stratium and is often caused by ________________________

behavioural and neurochemical sensitization

30

All the tissues and organs in your body are constructed of ________

cells