Flashcards in Tutorial week 11 Deck (115)
an ________________ involves using a laboratory animal in a specific testing situation to determine the behavioural changes induced by a drug, a genetic manipulation or some manipulation of the brain.
the utility of a behaviour test can be considered in terms of its _______________
a good behavioural test is one that can reliably predict useful outcomes in __________
___________ issues are important; the less invasive and harmful the test for the animal, the better it is
_____________________ currently spend $30 billion per year on R&D
the biggest area of research is _________________
there are currently 10,000 knockout mice and many thousands more types with random mutations.
animal models are very widely used in _____________ research
assessing acute and long-term effects of drugs, particularly drug abuse, on behaviour is important in __________________
how did the overall behaviour of rat given cannabis (THC) differ from the rat given placebo
THC - not moving; anxious
placebo - energetic
does the hot plate cause tissue damage to the rat? why?
No, the hot plate will only damage the tissue of the rats if they were to be placed in the hot plate for more than 86 seconds. temperature was set up to not exceed 86 seconds.
name some drugs that produce catalepsy in rats
THC, morphine, sedatives, benzodiazepine, and anti-psychotic drugs
what does an anxiolytic drug typically do to behaviour on the elevated plus maze
rats with placebo - they go to closed space
rats with THC - anxiety depression; they go to opened space
why must testing high doses of alcohol or benzodiazephine on the plus maze be problematic
it has sedative effects
feeling less anxious
what is the brand name for chlorodiazepoxide
describe the effects of high dose of amphetamine
what kind of drug can be given to block stereotype induced by amphetamine
what was the difference between pure THC and THC cannabidol on the reporter?
Pure THC- found in cannabis; psychoactive; paranoid; depressed
THC and cannabidol - she couldn't stop laughing; euphoric
what might be the effect of smoking marijuana that's been breed to contain high THC levels?
family history of risk factors - increase in THC will lead to depression
compare the reporter's response to THC to that of the rat earlier. what does this tell us about the utility of using a rat model for exploring the neurobiology of drugs on people?
confirmation that these drugs affects rats.
emotional effects that are applicable to humans.
___________ allows analgesuc properties of drugs to be assessed
the hot plate test
rats are placed on a hot plate at _____
50 degrees Celsius
the hot plate test is important when investigating new _____________
analgesic (pain relieving) grugs
____________ allows assessment of catalepsy
the bar test
a drug that increase response latency in this test has ___________ properties and may well impair _________ in human
cataleptogenic; motor function
____________________ is a common test for anxiety. it's not thought to examine a rat's fear of height, but rather it exploits the rat's natural fear of open spaces, and its preference for maintaining vibrissal contact with its environment.
elevated plus maze
normally, a rat in EPM will spend about ______ of its time in the enclosed arms
___________________ is repetitive, stereotyped, and seemingly purposely behaviour that is induced by high dose repeated doses of stimulant drugs.
stereotype is associated with a hyperdopaminergic state in the dorsal (where/spatial processing) and ventral (what/obj. processing) stratium and is often caused by ________________________
behavioural and neurochemical sensitization