TWW testicular ca indications (3 things)
solid intratesticular lump, non-painful enlargement/change in shape of testis, abnormal testicular US
TWW prostate ca indications (2 things)
feels malignant on DRE, PSA >age-related NR
TWW bladder ca indications (3 things)
> 45 y.o. + visible haematuia (persistent/recurrus after UTI Rx), >45 y.o. + unexplained visible haematuria w/o urinary symptoms, >60 y.o. + unexplained non-visible haematuria + dysuria/high WCC
TWW renal ca indications (3 things)
abnormal US suggestive of ca, >45 y.o. + visible haematuia (persistent/recurrus after UTI Rx), >45 y.o. + unexplained visible haematuria w/o urinary symptoms
TWW penile ca indications (3 things)
penile mass/ulcerated lesion (STI excluded), persistent penile lesion post-STI Rx, unexplained/persistent glans/foreskin symptoms
at what age to worry about visible haematuria
45
at what age to worry about non-visible haematuria
60
causes to rule out in visible/non-visible haematuria
UTI, stones, trauma, GN
TWW brain/CNS ca indications (9 things)
suspicious MRI/CT, new onset seizures (focal/interictal focal deficit), progressive sub-acute loss of central neuro funciton, unexplained rapid personality/behavioural/slowness/cognitive change, headache + sinister features suggestive of raised ICP, isolated new onset daily headache <12/52 duration, CN palsy, visulal changes, Hx of ca + neuro symptoms
f and duration of new onset headache to be suspicious
daily, <12/52
ASAP referral for retinoblastoma (1 thing)
absent red reflex in children
TWW for intraocular tumour (3 things)
unexplained vision loss, ux proptosis/globe displacement, CT/MRI suspicious
TWW ovarian ca indications (4 things)
suspicious abdo/pelvic US, ascites, pelvic/abdo mass, CA125 >35
TWW endometrial ca indications (2 things)
suspicious abdo/pelvic US, PMB (>12/12 post-last bleed)
TWW cervical ca indication (1 thing)
suspicious cervix appearance
TWW vaginal ca indication (1 thing)
unexplained palapble mass in/at entrance to vagina
TWW vulval ca indications (3 things)
unexplained lump, unexplained ulceration, unexplained bleeding
worry RE CA125 >
35
how long after menopause os PMB considered
12/12
TWW leukaemia indications (5 things)
abnormal FBC/blood film consistent with leukaemia, unexplained/persistent/recurrent infections, unexplained bruising, unexplained bleeding, unexplained petechiae
TWW myeloma indications (5 things)
protein electrophoresis suggestive of myeloma, urine BJ protein, > 40 y.o. + unexplained #, >40 y.o. + >6/52 bone pain, >40 y.o. + back pain + red flag
TWW lymphona indications (8 things)
unexplained lymphadenopathy, persistent lymphadenopathy > 6/52 >2cm, unexplained splenomegaly, fever, night sweats, SOB, pruitis, weight loss
leukaemia FBC
pancytopenia, anaemia, neutropaenia, thrombocytopaenia, may just be anaemia in the chronic cases
leukaemia blood film
blasts
unexplained bruising/bleeding/petechiae are suggestive of
leukaemia
protein found in the urine indicative of myeloma
Bence Jones
worry RE unexplained # >
40
duration + age > which we worry about bone pain
6/52, >40
back pain + red flag worry >
40
persistent lymphadenopathy duration + size
6/52, >2cm
TWW laryngeal/pharyngeal ca indications (6 things)
unexplained neck/throat lump/mass, >40 y.o. + horseness (>3/52), >4/52 persistent ux pain/discomfort in throat, >40 y.o. + dysphagia >3/52, >40 y.o. + odynophagia (3/52), >40 y.o. + otalgia (3/52)
TWW ear/nose/sinus ca indications (6 things)
persistent ux otalgia, serosanguinous nasal discharge >4/52, ux nasal obstruciton + purulent discharge, facial/CN palsy/neuropathy, orbital mass, severe facial pain
TWW thyroid ca indications (2 things)
unexplained solitary thyroid lump, suspicious US
TWW oral/lip ca indications (5 things)
> 3/52 unexplained oral ulceration, suspicious lump/mass on lip/in oral cavity, red/red + white patch in oral cavity (leukoplakia/erythroleukoplakia), tooth mobility w/o periodontal DZ, poor healing >3/52 post-tooth extraction
TWW salivary ca indications (2 things)
> 40 y.o. + unexplained/persistent parotid/submandibular swelling, firm submucosal swelling in oral cavity
worry about horseness/dysphagia/odynophagia/otalgia age + duration
> 40 y.o., >3/52
worry about persistent us discomfort/pain in throat
> 4/52
TWW power GI ca indications (9 things)
suspicious investigation (colonoscopy/flexisig), suspicious abdo/recctal mass, unexplained anal mass/ulceration, >40 y.o. + unexplained abdo pain + weight loss, >40 y.o. + unexplained Fe- anaemia, <50 y.o. + PR bleeding + abdo pain/change in bowel habits/weight loss/Fe- anaemia, >50 y.o. + unexplained PR bleeding, >50 y.o. + unexplained change in bowel habits, >60 y.o. + unexplained anaemia
worry RE abdo pain + weight loss >
40
worry RE unexplained Fe- anaemia >
40
worry RE PR bleeding + abdo pain/change in bowel habits/weight loss/Fe- anaemia
50
worry RE PR bleeding >
50
worry RE unexplained change in bowel habits >
50
worry RE unexplained anaemia >
60
TWW L ca indications (4 things)
suspicious CXR/CT, >40 y.o. + unexplained haemoptysis, >40 y.o. + unexplained finger clubbing/unexplained thrombocytosis/unexplained cervical/supraclavicular lymphadenopathy/unexplained chest signs/unexplained perssistent/recurrent chest infections, features of metastatic DZ
worry RE haemoptysis >
40
2WW melanoma indications (7 things)
major criteria: change in size, irregular shape, irregular colour
minor criteria: largest diameter >7mm, oozing, inflammation, change in sensation
2WW 1’ bone sarcoma indications (3 things)
suspicious XR, bone swelling/tenderness, bone pain not responding to simple analgesia
worry when mole diameter >
7mm
2WW oesophagus/stomach ca indicaitons (2 things)
suspicious endoscopy, upper abdo mass
2WW pancreas ca indications (2 things)
suspicious abdo CT/US, >40 y.o. + jaundice
2WW liver/GB ca indication (1 thing)
suspicious US
worry RE jaundice in >
40s
2WW breast ca indications (6 things)
breast lump, persistent/unexplained axilliary lump, ux nipple discharge (blood stained/serous)/retraction/ulceration/distortion/eczema resistent to topical steroids, skin changes (nodules, ulceration, peau d’orange, dimpling), ux non-cyclical breast pain, men > 50 y.o. + subareolar lump
worry RE breast lumps in men >
50