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Flashcards in Tx Psychosis Deck (41):
1

False perceptions

Hallucinations

2

False beliefs

Delusions

3

Psychosis caused by abnormalities in dopamine signaling in __________ and ____________ pathways

Mesolimbic
Mesocortical

4

Positive symptoms of schizophrenia result from _____________ of ______________
Respond well to ______________

hyperactivation
mesolimbic
neuroleptics (typical antipsychotics)

5

Negative symptoms of schizophrenia result from ______________ of ___________
Respond to ____________

Hypoactivity
Mesocortical
Atypical antipsychotics

6

Apathy, affective flattening, lack of motivation, lack of pleasure, poverty of speech, social isolation

Negative sxs

7

Agitation, delusions, disorganized speech, disorganized thinking, hallucinations, insomnia

Positive sxs

8

Antipsychotic drugs are called neuroleptics because they suppress ______ activity and ______________

motor
emotional expression

9

Antipsychotics block _______ and _________ receptors

Dopamine (D2)
Serotonin

10

Typical antipsychotics target

D2 receptor

11

Atypical antipsychotics target

serotonin receptor

12

Presynaptic effect
Short term -
Long term -

Activated neurons
Inactivated neurons

13

Postsynaptic effect
Short term -
Long term -

Receptor blockade
Receptor supersensitivity

14

Treats tourette's and huntingtons

Haloperidol

15

Do not use in pts with seizures. Lowers threshold

chlorpromazine

16

Treats hiccough.
Deposits in lens and cornea

Chlorpromazine

17

Deposits in retina at higher doses

Thioridazine

18

Treats drug induced nausea (chemo)

Prochlorperazine

19

Motion sickness

Scopolamine

20

Component of neuroleptanesthesia

Droperidol

21

All except _____ and ________ can be used as anti-emetics (block dopamine receptors in CTZ)

aripiprazole
thioridazine

22

Drugs targeting dopamine receptors have ________ side effects

extrapyramidal

23

Targeting this receptor can cause pseudoparkinsonism and dystonias

Dopamine

24

Targeting dopamine receptor can cause ______________. Abnormal facial and oral movements.
Results from ____________ to dopamine

Tardive dyskinesia
Supersensitivity

25

Potentially fatal, caused by targeting dopamine receptor.
Muscle rigidity, elevated temp, altered consciousness, autonomic dysfn (tachycardia, diaphoresis, tachpnea, urinary and fetal incontinence)

Neuroleptic malignant syndrome

26

Target dopamine receptors can cause increases in serum ________

prolactin

27

__________ have lower incidence of extrapyramidal side effects

atypicals

28

Haloperidol, fluphenazine, and thiothixene cause

extrapyramidal side effects

29

Thioridazine and chlorpromazine have strong ___________ effects and less ____________ effects

anticholinergic
extrapyramidal

30

Typical antipsychotics more commonly cause _____________

tardive dyskinesia and neuroleptic malignant syndrome

31

Phenothiazines cause increases in ___________

prolactin

32

Use trihexyphenidyl, benztropine mesylate, biperidin, and procyclidine HCL to treat

extrapyramidal effects from targeting D2 receptor

33

Stop antipsychotic immediately. Administer bromocriptine and dantrolene. Cool patient if high temp maintined

neuroleptic malignant syndrome

34

Mesoridzine and perphenazine associated with

menstrual irregularities, loss of libido, swelling of mamillary glands, galactorrhea, osteroporosis

35

Dry mouth, blurred vision, urinary retention, constipation, confusion with targeting

cholinergic muscarinic receptor

36

Thioridazine, chlorpromazine, and olanzapine also target ______ receptor. ___________ does all of these things and also increases salivation

muscarinic
clozapine

37

Chlorpromazine and mesoridazine target _____ receptors and cause ____________. May result in syncope and inhibition of ejaculation

adrenergic
orthostatic hypotension

38

Chlorpromazine, olanzapine, quetiapine, and clozapine target

Histamine receptor

39

Metabolic side effects more common with ______

atypical antipsychotics

40

Clozapine, olanzapine, and chlorpromazine associated with

weight gain, lipids, and glucose

41

Gross disturbances in comprehension of reality, false perceptions, and false beliefs

Psychosis