Types of Screening

Question 1

Random Screening

Answer 1

no effort to bias the set of screened compounds based on prior knowledge of the target or its known ligands

Question 2

Targeted Screening

Answer 2

some prior knowledge to intelligently select compounds that are judged most likely to interact with a target

Question 3

Fragment based Screening

Answer 3

screening methods using xray crystallography or NMR to identify simple molecules with modest affinity for a target, with intent of connecting two or more fragments to create a useful lead

Question 4

Computational approaches

Answer 4

with the knowledge of the binding site in the target or of the structure of several known ligands; may be used to design lead compounds