Flashcards in Ulcerative Colitis Deck (26):
What are the two disease that are inflammatory bowl disease?
What does Ulcerative colitis affect?
What is the cytokine profile of Ulcerative colitis?
What are the genetic factors for Ulcerative colitis?
What effect does smoking have on Ulcerative colitis?
Describe the pathology of Ulcerative Colitis?
Distortion of the crypts
Infiltration of Monocytes and Neutropphils
Inflammation and Ulceration of Mucosa
What layer is affected by Ulcerative colitis inflammation?
What cells drive the pathology of Ulcerative colitis?
NK T cells
What Inflammation cytokines are produced in Ulcerative colitis?
What are the symptoms of Ulcerative Colitis?
Episodic/ Chronic Diarrhoea
Blood in stool
What is treatment for severe ulcerative colitis?
What is the pharmacological treatment for Ulcerative colitis?
5- ASA (Mesalazine)
What is the mechanism of action of 5ASA?
Reduces risk of colon cancer
How does an oral 5-asa work for delivery of medication?
It is a prodrug - a side chain needs cleaved off to become active
pH dependent release
What topical methods of delivery are there for 5 -ASA?
Suppositories (Coat the rectum only)
Enemas (Coat the rectum and sigmoid colon)
What 5-ASA drug that causes side effects and why?
It has a sulphapyridine ring
What 5-ASA drug is pH dependent?
What is the best topical therapy for Ulcerative colitis?
What is given if 5-ASA is not working? - What is the purpose and course of this drug?
High dose initially - reduced over 6-8 weeks.
What is the surgical treatment for ulcerative colitis?
Restorative proctocoloectomy and pouch
What is the therapy pyramid for IBD?
Steroids (for short course)
What levels in the blood must be done to see if imunosupressive therapy is appropriate?
What surgery is done for Ulcerative colitis?
Proctocolectomy with end ileostomy
Proctocolectomy with ileorectal anastomosis
What are the indications for surgery fro UC?
Medically unresponsive disease
Growth retardation in children
Attempted resolution of extra-intestinal disease
What are the complications of a pouch?