Ulcerative Colitis & Cronh's D Flashcards Preview

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Flashcards in Ulcerative Colitis & Cronh's D Deck (27):
1

- Ulcerative colitis (UC): is an inflammatory disease of the large intestine. Ulcers form in the inner lining, or *mucosa* of the colon or rectum often resulting in diarrhea, blood, and pus
- Crohn's Disease (CD): is an inflammatory that extended into the deeper layer of the intestinal wall. It's most often in the ileum and the cecum

- Suggested tx algorithm

- Start with mesalamine => corticosteroid => immune suppressant
- Allergy to mesalamine, start with corticosteroid
- If allergy to sulfa, do not use sulfasalazine

2

Lialda

- Administration instruction
- Special about this tab
----- for all 5-ASA----
- C/I
- SEs
- Urine color:

Mesalamine (5-ASA) DR

- Dose: 2-4 tabs QD w/ FOOD. Do not crush or chew.
- Tab is coated with a pH dependent polymer film, which breaks down at or above pH 6.8
-----
- Similar to ASA. Avoid in salicylate sensitivity
- SEs: HA, abdominal pain, fever, rash
- Discolor of urine yellow-brown

3

Asacol HD

- Dose/frequency

Mesalamine High Dose

- DR: 800 - 1600mg TID. Swallow whole tab

4

Delzicol

- Direction to take

Mesalamine DR

- Take on EMPTY stomach: 1H b/4 meal or 2H after

5

Pentasa

- Dose

Mesalamine CR

- Dose: 1g QID

6

Canasa

- Dose

Mesalamine rectal suppository

- Dose: 1000mg QHS. Retain for 1-3hrs to achieve max benefit.

7

Rowasa

- Dose
- Counseling point regarding suppository

Mesalamine rectal suspension enema

- Take 4g/60mL QHS. Retain over night ~ 8H

Counseling:
- Pt must use promptly once foil wrap is removed. If contents darken (dark brown), discard

8

Colazal

- Frequency
- Prodrug
- CI

Balsalazide

- Giazo: UC in males (three 1.1g tab BID x 8wks
- Balsalazide cleaved in the colon to produce mesalamine.
- Frequency: TID
- CI: salicylate allergy

9

Azulfidine

- C/I
- SE
- Monitor
- Body fluid
- Indication

Sulfasalazine (DMARD)

- C/I: sulfa and aspirin allergy
- SEs: HA, skin rash, hepatitis, kidney inflammation, infertility, impaired folate absorption, BMS
- Monitor: LTF, CBC, CNS
- Body fluid: turn orange yellow
- I: UC, RA

10

Uceris

- Indication
- Frequency

Budesonide

- Indication: UC
- Frequency: QD AM

11

Medrol

- Dose

Methylprednisolone

- Dose: 35-40mg/day PO QAM

12

Cortef

- Dose

Hydrocortisone

- 200-300 mg/d PO QAM

13

Cortenema

Hydrocortisone enema

14

Cortifoam

Hydrocortisone acetate rectal foam

15

Sandimmune

- Indication

Cyclosporine

- Indication: UC when refractory to corticosteroid (off-label), psoriasis, rheumatoid arthritis, solid organ transplant, GVHD,

16

Remicade

- Class
- Frequency
- Indication

Infliximab

- Class: TNF-blocker
- Frequency: Start at 0, 2, 6 week then Q8W
Indication:
- UC that refractory to corticosteroid
- Crohn disease
- Ankylosing spondylitis
- Psoriatic arthritis
- Rheumatoid arthritis

17

Humira

- Class
- Frequency
- Indication

Adalimumab SQ

- Class: TNF-blocer
- Frequency: Q2W

Indication:
- Ankylosing spondylitis
- Crohn Disease/UC
- Juvenile idiopathic arthritis
- Plaque psoriasis
- Psoriasis arthritis

18

Cimzia

- Class
- Frequency
- Indication

Certrolizumab SQ

- Class: TNF-blocer
- Frequency: Q4W
Indication:
- Ankylosing spondylitis
- Crohn Disease
- UC
- Psoriatic arthritis
- Rheumatoid arthritis

19

Simponi

- Class
- Indication

Golimumab

- Class: TNF-blocer

Indication:
- UC
- Ankylosing spondylitis
- Psoriatic arthritis
- Rheumatoid arthritis

20

Imuran

- Indication

Azathioprine

Indication
- Renal transplant
- Rheumatoid arthritis
- UC (off label)

21

Purinethol
Purixan

- Indication

6-Mercaptopurine


Indication
- UC (off label)
- Crohn's Disease
- ALL/APL (P = promyelocytic)

22

Entocort

- Indication

Budesonide

- Indication: Crohn's Disease

23

Dipentum

Olsalazine

24

Apriso

- Frequency

Mesalamine

- PO QD AM

25

Giazo

- Indication
- Frequency
- C/I

Balsalazine

- I: UC in man
- Frequency: BID
- C/I aspirin allergy

26

Solu-Medrol

- Form

Methyprednisolone

- IV 40mg QD

27

Entyvio

- Indication
- Form

Vedolizumab

- I: Crohn's D and UC
- Form: IV