Flashcards in Unit 1-Gastro Deck (42):
Distribution of H2 blocker
Throughout body-including breast milk and placenta
How many days is the 3 drug Tx. For H. Pylori?
Contraindications of misoprostol
Pregnancy-may cause miscarriage.
Interactions of PPIs.
Decrease absorption of meds that require acidic env. To be absorbed.
Elimination of H2 blocker.
Through urine. (Adjust dose if renal impairment)
Gastric acid secretion is stimulated by:
When to administer antacids with other meds.
1-2 hrs before or 4-6 hrs after.
MOA of PPI
Block gastric acid secretion by inhibiting gastric H+ pump. Prevents acid from entering stomach. (Blocks very well).
Antibiotics for 3 drug H. Pylori tx
Amoxicillin OR metronidazole
Why can parenteral and rectal routes of NSAIDS still cause peptic ulcers?
If a patient can’t swallow a PPI capsule what else can you do?
Opened and mix into applesauce
Adverse effects of misoprostol.
The primary way NSAIDS cause ulcers.
Systemic inhibition of endogenous mucosal prostaglandin synthesis.
70% of tx failures of H. Pylori are caused by___________
H2 blockers work w/in_______and last _____Hrs
30 min. 12 hrs.
Pepsin in inactive if pH is _____.
Magnesium hydroxide/aluminum hydroxide
Common adverse effects of PPI.
Headache. Diarrhea. Constipation. Abdominal pain.
Cimetidine inhibits _________
MOA of sucralfate.
Not absorbed-forms complex by binding to positively charged proteins in GI tract-forms a paste-like adhesive substance that protects ulcerated area against gastric acid/pepsin/bile salts.
ALLOWS ULCERS TO HEAL
PPI may take _____days to reach efficacy.
Use for misoprostol.
Reduce risk of NSAID-induced gastric ulcers in patients at high risk of ulcer complications. (Would prefer PPIs)
Adverse effects of bismuth subsalicylate.
Black tongue. Dark stools
Which PPI is the strongest CYP2C19 inhibitor?
MOA of misoprostol.
Acts like a prostaglandin-synthetic prostaglandin analog that inhibits secretion of acid and stimulates secretion of mucus and bicarbonate.
MOA of H2 blocker.
Inhibit histamine H2 receptors in gastric parietal cells to reduce secretion of gastric acid.
Adverse effects of antacids:
Constipation-calcium, aluminum products
Acid base disturbances-sodium bicarbonate (not for long term use)
Changes in mineral metabolism
Absorption of cations-if renal impairment (Mg, Al, Ca)
PPI metabolized by________.
Gastric acid secretion is inhibited by:
Prostaglandins (NSAIDS-cause ulcers).
MOA of antacids:
Weak bases that react with gastric acid to rom water and a salt. Diminishes acidity of stomach.
Important to remember when taking metronidazole.
Drugs that antacid interacts with: