Unit 1-Gastro Flashcards Preview

PHARMACOLOGY SPRING 2018 > Unit 1-Gastro > Flashcards

Flashcards in Unit 1-Gastro Deck (42):
1

Distribution of H2 blocker

Throughout body-including breast milk and placenta

2

NIzatidine

H2 blocker

3

How many days is the 3 drug Tx. For H. Pylori?

10-14

4

Contraindications of misoprostol

Pregnancy-may cause miscarriage.

5

Interactions of PPIs.

Decrease absorption of meds that require acidic env. To be absorbed.

6

Magnesium hydroxide

Antacid

7

Elimination of H2 blocker.

Through urine. (Adjust dose if renal impairment)

8

Famotidine

H2 blocker

9

Gastric acid secretion is stimulated by:

Acetylcholine.
Histamine.
Gastrin.

10

When to administer antacids with other meds.

1-2 hrs before or 4-6 hrs after.

11

MOA of PPI

Block gastric acid secretion by inhibiting gastric H+ pump. Prevents acid from entering stomach. (Blocks very well).

12

Sodium bicarbonate

Antacid

13

Antibiotics for 3 drug H. Pylori tx

Clarithromycin
Amoxicillin OR metronidazole

14

Misoprostol dosing.

4x/day

15

Why can parenteral and rectal routes of NSAIDS still cause peptic ulcers?

COX1 blocking

16

If a patient can’t swallow a PPI capsule what else can you do?

Opened and mix into applesauce

17

Adverse effects of misoprostol.

Abdominal pain.
Flatulence.
Diarrhea
Nausea

18

The primary way NSAIDS cause ulcers.

Systemic inhibition of endogenous mucosal prostaglandin synthesis.

19

70% of tx failures of H. Pylori are caused by___________

Antimicrobial resistance

20

H2 blockers work w/in_______and last _____Hrs

30 min. 12 hrs.

21

Pepsin in inactive if pH is _____.

>4

22

Magnesium hydroxide/aluminum hydroxide

Antacid

23

Common adverse effects of PPI.

Headache. Diarrhea. Constipation. Abdominal pain.

24

Cimetidine inhibits _________

CYPP450s

25

MOA of sucralfate.

Not absorbed-forms complex by binding to positively charged proteins in GI tract-forms a paste-like adhesive substance that protects ulcerated area against gastric acid/pepsin/bile salts.

ALLOWS ULCERS TO HEAL

26

Cimetidine

H2 blocker

27

PPI may take _____days to reach efficacy.

1-3

28

Use for misoprostol.

Reduce risk of NSAID-induced gastric ulcers in patients at high risk of ulcer complications. (Would prefer PPIs)

29

Ranitidine

H2 blocker

30

Adverse effects of bismuth subsalicylate.

Black tongue. Dark stools
Salicylic

31

Which PPI is the strongest CYP2C19 inhibitor?

Omeprazole.

32

MOA of misoprostol.

Acts like a prostaglandin-synthetic prostaglandin analog that inhibits secretion of acid and stimulates secretion of mucus and bicarbonate.

33

Calcium carbonate

Antacid

34

MOA of H2 blocker.

Inhibit histamine H2 receptors in gastric parietal cells to reduce secretion of gastric acid.

35

Adverse effects of antacids:

Constipation-calcium, aluminum products

Diarrhea-magnesium products

Acid base disturbances-sodium bicarbonate (not for long term use)

Changes in mineral metabolism

Absorption of cations-if renal impairment (Mg, Al, Ca)

36

PPI metabolized by________.

CYP450

37

Gastric acid secretion is inhibited by:

Prostaglandins (NSAIDS-cause ulcers).

38

MOA of antacids:

Weak bases that react with gastric acid to rom water and a salt. Diminishes acidity of stomach.

39

“Prazole”

PPI

40

Important to remember when taking metronidazole.

Avoid alcohol

41

Drugs that antacid interacts with:

Ferrous sulfate
Isoniazid
Sulfonylureas
Fluoroquinolones

42

Adverse effects of sucralfate

Constipation.
Nausea
Metallic taste
Aluminum toxicity(more likely if renal failure)